拼接因子
RNA剪接
选择性拼接
脆弱性(计算)
转移
生物
癌症研究
癌症
核糖核酸
基因
信使核糖核酸
遗传学
计算机科学
计算机安全
作者
Kevin Coughlin,Ledong Wan
摘要
In this issue of JEM, Krishnamoorthy et al. (https://doi.org/10.1084/jem.20241029) identify the loss of the splicing factor RBM10 as a driver of metastasis in thyroid cancer through the regulation of RNA splicing. The synthetic lethal interaction between NF-κB and RBM10 loss reveals a potential therapeutic vulnerability.
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