Fabrication of Novel 3-D Nanocomposites of HAp–TiC–h-BN–ZrO2: Enhanced Mechanical Performances and In Vivo Toxicity Study for Biomedical Applications

材料科学 纳米复合材料 制作 体内 纳米技术 毒性 复合材料 化学 医学 替代医学 生物技术 有机化学 病理 生物
作者
Sarvesh Kumar Avinashi,Shweta,Bhavna Bohra,Rajat Kumar Mishra,Savita Kumari,Zaireen Fatima,Ajaz Hussain,Bhagawati Saxena,Saurabh Kumar,Monisha Banerjee,Chandkiram Gautam
出处
期刊:ACS Biomaterials Science & Engineering [American Chemical Society]
卷期号:10 (4): 2116-2132 被引量:5
标识
DOI:10.1021/acsbiomaterials.3c01478
摘要

Due to excellent biocompatibility, bioactivities, and osteoconductivity, hydroxyapatite (HAp) is considered as one of the most suitable biomaterials for numerous biomedical applications. Herein, HAp was fabricated using a bottom-up approach, i.e., a wet chemical method, and its composites with TiC, h-BN, and ZrO2 were fabricated by a solid-state reaction method with enhanced mechanical and biological performances. Structural, surface morphology, and mechanical behavior of the fabricated composites were characterized using various characterization techniques. Furthermore, transmission electron microscopy study revealed a randomly oriented rod-like morphology, with the length and width of these nanorods ranging from 78 to 122 and from 9 to 13 nm. Moreover, the mechanical characterizations of the composite HZBT4 (80HAp–10TiC–5h-BN–5ZrO2) reveal a very high compressive strength (246 MPa), which is comparable to that of the steel (250 MPa), fracture toughness (14.78 MPa m1/2), and Young's modulus (1.02 GPa). In order to check the biocompatibility of the composites, numerous biological tests were also performed on different body organs of healthy adult Sprague-Dawley rats. This study suggests that the composite HZBT4 could not reveal any significant influence on the hematological, serum biochemical, and histopathological parameters. Hence, the fabricated composite can be used for several biological applications, such as bone implants, bone grafting, and bone regeneration.
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