材料科学
体内
生物相容性
润滑
聚合物
润滑油
摩擦学
纳米技术
软骨
透明质酸
生物医学工程
复合材料
生物
生物技术
冶金
医学
解剖
作者
Duy Anh Phạm,Chang‐Sheng Wang,Line Séguy,Hu Zhang,Sabrina Benbabaali,Jimmy Faivre,Sotcheadt Sim,Guojun Xie,Mateusz Olszewski,Jean‐Michel Rabanel,Florina Moldovan,Krzysztof Matyjaszewski,Xavier Banquy
标识
DOI:10.1002/adma.202401689
摘要
Abstract Bottlebrush polymers (BB) have emerged as compelling candidates for biosystems to face tribological challenges, including friction and wear. This study provides a comprehensive assessment of an engineered triblock BB polymer's affinity, cell toxicity, lubrication, and wear protection in both in vitro and in vivo settings, focusing on applications for conditions like osteoarthritis and dry eye syndrome. Results show that the designed polymer rapidly adheres to various surfaces (e.g., cartilage, eye, and contact lens), forming a robust, biocompatible layer for surface lubrication and protection. The tribological performance and biocompatibility are further enhanced in the presence of hyaluronic acid (HA) both in vitro and in vivo. The exceptional lubrication performance and favorable interaction with HA position the synthesized triblock polymer as a promising candidate for innovative treatments addressing deficiencies in bio‐lubricant systems.
科研通智能强力驱动
Strongly Powered by AbleSci AI