Recent advances in phage defense systems and potential overcoming strategies

噬菌体 噬菌体疗法 生物 细菌 基因转移 抗生素耐药性 计算生物学 微生物学 抗生素 基因 遗传学 大肠杆菌
作者
Xiaoming Yuan,Zhichao Huang,Zhenjun Zhu,Jumei Zhang,Qingping Wu,Liang Xue,Juan Wang,Yu Ding
出处
期刊:Biotechnology Advances [Elsevier]
卷期号:65: 108152-108152 被引量:6
标识
DOI:10.1016/j.biotechadv.2023.108152
摘要

Bacteriophages are effective in the prevention and control of bacteria, and many phage products have been permitted and applied in the field. Because bacteriophages are expected to replace other antimicrobial agents like antibiotics, the antibacterial effect of bacteriophage has attracted widespread attention. Recently, the diversified defense systems discovered in the target host have become potential threats to the continued effective application of phages. Therefore, a systematic summary and in-depth illustration of the interaction between phages and bacteria is conducive to the development of this biological control approach. In this review, we introduce different defense systems in bacteria against phages and emphasize newly discovered defense mechanisms in recent years. Additionally, we draw attention to the striking resemblance between defense system genes and antibiotic resistance genes, which raises concerns about the potential transfer of phage defense systems within bacterial populations and its future impact on phage efficacy. Thus, attention should be given to the effects of phage defense genes in practical applications. This article is not exhaustive, but strategies to overcome phage defense systems are also discussed to further promote more efficient use of phages.
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