[Application and progress of photodynamic therapy in combination therapy of lung cancer].

Lung cancer is one of the most common malignant tumors with high morbidity and mortality. At present, the traditional treatments of lung cancer include surgical resection, radiotherapy, chemotherapy, targeted therapy and immunological therapy. The modern model of diagnosis and treatment tends to be multidisciplinary, individual, focusing on systemic therapy combined with local therapy. Recently, PDT(photodynamic therapy) becomes an emerging cancer treatment due to its advantages of low trauma, high selectivity, hypotoxicity, good reutilization. PDT has a good effect in the radical treatment of early airway cancer and palliative treatment of advanced airway tumor by using its photochemical reactions. Nevertheless, more attention is focused on combination therapy of PDT Combination with surgery can reduce tumor burden and eliminate potential lesions; Combination with radiotherapy can reduce the amount of radiation and improve therapeutic effect; Combination with chemotherapy achieves the combination of local and systemic therapy; Combination with targeted therapy can enhance anti-cancer targeting; combination with immunotherapy can improve anti-cancer immunity, etc. This article focused on PDT as a part of a combination therapy in the treatment of lung cancer, to provide a new treatment method for patients with poor therapeutic effect with traditional treatment.肺癌是恶性肿瘤中最常见的一种，其发病率和病死率居高不下。目前肺癌的传统治疗手段包括手术切除、放射治疗、化学治疗，靶向治疗、免疫治疗也日渐成熟。现代诊疗模式趋于多学科、个体化及全身治疗联合局部治疗。近年来光动力疗法（photodynamic therapy，PDT）以微创性、高选择性、低毒性、可重复利用等特点成为一种新兴的癌症治疗方式，在泌尿系统、消化系统、呼吸系统均有良好的适用性。PDT利用其光化学反应在早期气道恶性肿瘤根治性治疗及晚期气道肿瘤姑息性治疗中有良好的成效。但越来越多人关注PDT的联合治疗模式，如联合手术可减轻瘤负荷或消除潜在病灶；联合放疗可减少接受的辐射总量并改善疗效；联合化疗实现局部与全身抗癌结合；联合靶向治疗增强抗癌药物的靶向性；联合免疫治疗增强抗肿瘤免疫等。本文关注PDT作为综合治疗的一部分在肺癌治疗中的临床应用及进展，以期为传统治疗效果不佳的患者提供一种新的治疗手段。.