Endocrine effects of exposure to artificial light at night: A review and synthesis of knowledge gaps

Animals have evolved with natural patterns of light and darkness, such that light serves as an important zeitgeber, allowing adaptive synchronization of behavior and physiology to external conditions. Exposure to artificial light at night (ALAN) interferes with this process, resulting in dysregulation of endocrine systems. In this review, we evaluate the endocrine effects of ALAN exposure in birds and reptiles, identify major knowledge gaps, and highlight areas for future research. There is strong evidence for ecologically relevant levels of ALAN acting as an environmental endocrine disruptor. However, most studies focus on the pineal hormone melatonin, corticosterone release via the hypothalamus-pituitary-adrenal axis, or regulation of reproductive hormones via the hypothalamus-pituitary-gonadal axis, leaving effects on other endocrine systems largely unknown. We call for more research spanning a diversity of hormonal systems and levels of endocrine regulation (e.g. circulating hormone levels, receptor numbers, strength of negative feedback), and investigating involvement of molecular mechanisms, such as clock genes, in hormonal responses. In addition, longer-term studies are needed to elucidate potentially distinct effects arising from chronic exposure. Other important areas for future research effort include investigating intraspecific and interspecific variability in sensitivity to light exposure, further distinguishing between distinct effects of different types of light sources, and assessing impacts of ALAN exposure early in life, when endocrine systems remain sensitive to developmental programming. The effects of ALAN on endocrine systems are likely to have a plethora of downstream effects, with implications for individual fitness, population persistence, and community dynamics, especially within urban and suburban environments.