Counseling in fetal medicine: update on mild and moderate fetal ventriculomegaly

Ultrasound in Obstetrics & GynecologyVolume 63, Issue 2 p. 153-163 Opinion Counseling in fetal medicine: update on mild and moderate fetal ventriculomegaly D. Di Mascio, D. Di Mascio orcid.org/0000-0002-6560-3393 Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, ItalySearch for more papers by this authorF. D'Antonio, Corresponding Author F. D'Antonio [email protected] orcid.org/0000-0002-7546-8025 Center for Fetal Care and High-Risk Pregnancy, Department of Obstetrics and Gynecology, University of Chieti, Chieti, Italy Correspondence. (e-mail: [email protected])Search for more papers by this authorG. Rizzo, G. Rizzo orcid.org/0000-0002-5525-4353 Department of Obstetrics and Gynecology, Fondazione Policlinico Tor Vergata, University of Rome Tor Vergata, Rome, ItalySearch for more papers by this authorG. Pilu, G. Pilu Obstetric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalySearch for more papers by this authorA. Khalil, A. Khalil orcid.org/0000-0003-2802-7670 Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, University of London, London, UK Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK Fetal Medicine Unit, Liverpool Women's Hospital, University of Liverpool, Liverpool, UKSearch for more papers by this authorA. T. Papageorghiou, A. T. Papageorghiou Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK Oxford Maternal and Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UKSearch for more papers by this author D. Di Mascio, D. Di Mascio orcid.org/0000-0002-6560-3393 Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, ItalySearch for more papers by this authorF. D'Antonio, Corresponding Author F. D'Antonio [email protected] orcid.org/0000-0002-7546-8025 Center for Fetal Care and High-Risk Pregnancy, Department of Obstetrics and Gynecology, University of Chieti, Chieti, Italy Correspondence. (e-mail: [email protected])Search for more papers by this authorG. Rizzo, G. Rizzo orcid.org/0000-0002-5525-4353 Department of Obstetrics and Gynecology, Fondazione Policlinico Tor Vergata, University of Rome Tor Vergata, Rome, ItalySearch for more papers by this authorG. Pilu, G. Pilu Obstetric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalySearch for more papers by this authorA. Khalil, A. Khalil orcid.org/0000-0003-2802-7670 Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, University of London, London, UK Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK Fetal Medicine Unit, Liverpool Women's Hospital, University of Liverpool, Liverpool, UKSearch for more papers by this authorA. T. Papageorghiou, A. T. Papageorghiou Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK Oxford Maternal and Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UKSearch for more papers by this author First published: 19 May 2023 https://doi.org/10.1002/uog.26251Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Open Research DATA AVAILABILITY STATEMENT Data sharing not applicable to this article as no datasets were generated or analysed during the current study. References 1Achiron R, Schimmel M, Achiron A, Mashiach S. Fetal mild idiopathic lateral ventriculomegaly: is there a correlation with fetal trisomy? Ultrasound Obstet Gynecol 1993; 3: 89–92. 10.1046/j.1469-0705.1993.03020089.x CASPubMedWeb of Science®Google Scholar 2Alagappan R, Browing PD, Laorr A, McGahan JP. Distal lateral ventricular atrium: reevaluation of normal range. Radiology 1994; 193: 405–408. 10.1148/radiology.193.2.7972753 CASPubMedWeb of Science®Google Scholar 3Nomura ML, Barini R, De Andrade KC, Milanez H, Simoni RZ, Peralta CF, Machado IN, Zambelli H, Maio KT. Congenital hydrocephalus: gestational age and neonatal outcomes. Arch Gynecol Obstet 2010; 282: 607–611. 10.1007/s00404-009-1254-2 PubMedWeb of Science®Google Scholar 4Garel C, Luton D, Oury JF, Gressens P. Ventricular dilatations. Childs Nerv Syst 2003; 19: 517–523. 10.1007/s00381-003-0795-0 PubMedWeb of Science®Google Scholar 5Signorelli M, Tiberti A, Valsariati D, Molin E, Cerri V, Groli C, Bianchi UA. Width of fetal lateral ventricular atrium between 10 and 12 mm: a simple variation of the norm? Ultrasound Obstet Gynecol 2004; 23: 14–18. 10.1002/uog.941 CASPubMedWeb of Science®Google Scholar 6Shizuo OI. Controversies in definition and classification of hydrocephalus. Neurol Med Chir 2010; 50: 859–869. 10.2176/nmc.50.859 PubMedWeb of Science®Google Scholar 7Melchiorre K, Bhide A, Gika AD, Pilu G, Papageorghiou AT. Counseling in isolated mild fetal ventriculomegaly. Ultrasound Obstet Gynecol 2009; 34: 212–224. 10.1002/uog.7307 CASPubMedWeb of Science®Google Scholar 8Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Schünemann HJ; GRADE Working Group. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008; 336: 924–926. 10.1136/bmj.39489.470347.AD PubMedWeb of Science®Google Scholar 9 Society for Maternal–Fetal Medicine (SMFM); Fox NS, Monteagudo A, Kuller JA, Craigo S, Norton ME. Mild fetal ventriculomegaly: diagnosis, evaluation, and management. Am J Obstet Gynecol 2018; 219: B2–B9. 10.1016/j.ajog.2018.04.039 Web of Science®Google Scholar 10Falip C, Blanc N, Maes E, Zaccaria I, Oury JF, Sebag G, Garel C. Postnatal clinical and imaging follow-up of infants with prenatal isolated mild ventriculomegaly: a series of 101 cases. Pediatr Radiol 2007; 37: 981. 10.1007/s00247-007-0582-2 PubMedWeb of Science®Google Scholar 11Griffiths PD, Brackley K, Bradburn M, Connolly DJA, Gawne-Cain ML, Griffiths DI, Kilby MD, Mandefield L, Mooney C, Robson SC, Vollmer B, Mason G. Anatomical subgroup analysis of the MERIDIAN cohort: ventriculomegaly. Ultrasound Obstet Gynecol 2017; 50: 736. 10.1002/uog.17475 CASPubMedWeb of Science®Google Scholar 12Bar-Yosef O, Barzilay E, Dorembus S, Achiron R, Katorza E. Neurodevelopmental outcome of isolated ventriculomegaly: a prospective cohort study. Prenat Diagn 2017; 37: 764–768. 10.1002/pd.5078 PubMedWeb of Science®Google Scholar 13Meyer R, Bar-Yosef O, Barzilay E, Hoffman D, Toussia-Cohen S, Zvi E, Achiron R, Katorza E. Neurodevelopmental outcome of fetal isolated ventricular asymmetry without dilation: a cohort study. Ultrasound Obstet Gynecol 2018; 52: 467–472. 10.1002/uog.19065 CASPubMedWeb of Science®Google Scholar 14Malinger G, Paladini D, Haratz KK, Monteagudo A, Pilu GL, Timor-Tritsch IE. ISUOG Practice Guidelines (updated): sonographic examination of the fetal central nervous system. Part 1: performance of screening examination and indications for targeted neurosonography. Ultrasound Obstet Gynecol 2020; 56: 476–484. 10.1002/uog.22145 CASPubMedWeb of Science®Google Scholar 15Guibaud L. Fetal cerebral ventricular measurement and ventriculomegaly: time for procedure standardization. Ultrasound Obstet Gynecol 2009; 34: 127–130. 10.1002/uog.6456 CASPubMedWeb of Science®Google Scholar 16Paladini D, Malinger G, Birnbaum R, Monteagudo A, Pilu G, Salomon LJ, Timor-Tritsch IE. ISUOG Practice Guidelines (updated): sonographic examination of the fetal central nervous system. Part 2: performance of targeted neurosonography. Ultrasound Obstet Gynecol 2021; 57: 661–671. 10.1002/uog.23616 CASPubMedWeb of Science®Google Scholar 17Guibaud L, Lacalm A. Etiological diagnostic tools to elucidate 'isolated' ventriculomegaly. Ultrasound Obstet Gynecol 2015; 46: 1–11. 10.1002/uog.14687 CASPubMedWeb of Science®Google Scholar 18Vinals F, Correa F, Goncalves, Pereira PM. Anterior and posterior complexes: a step towards improving neurosonographic screening of midline and cortical anomalies. Ultrasound Obstet Gynecol 2015; 46: 585–594. 10.1002/uog.14735 CASPubMedWeb of Science®Google Scholar 19Pagani G, Thilaganathan B, Prefumo F. Neurodevelopmental outcome in isolated mild fetal ventriculomegaly: systematic review and meta-analysis. Ultrasound Obstet Gynecol 2014; 44: 254–260. 10.1002/uog.13364 CASPubMedWeb of Science®Google Scholar 20Chang Q, Yang Y, Peng Y, Liu S, Li L, Deng X, Yang M, Lan Y. Prenatal detection of chromosomal abnormalities and copy number variants in fetuses with ventriculomegaly. Eur J Paediatr Neurol 2020; 25: 106–112. 10.1016/j.ejpn.2020.01.016 PubMedWeb of Science®Google Scholar 21Wang J, Zhang Z, Li Q, Zhu H, Lai Y, Luo W, Liu S, Wang H, Hu T. Prenatal diagnosis of chromosomal aberrations by chromosomal microarray analysis in fetuses with ventriculomegaly. Sci Rep 2020; 10: 20765. 10.1038/s41598-020-77400-8 CASPubMedWeb of Science®Google Scholar 22Finckh U, Schröder J, Ressler B, Veske A, Gal A. Spectrum and detection rate of L1CAM mutations in isolated and familial cases with clinically suspected L1-disease. Am J Med Genet 2000; 92: 40–46. 10.1002/(SICI)1096-8628(20000501)92:1<40::AID-AJMG7>3.0.CO;2-R CASPubMedWeb of Science®Google Scholar 23Gil MM, Accurti V, Santacruz B, Plana MN, Nicolaides KH. Analysis of cell-free DNA in maternal blood in screening for aneuploidies: updated meta-analysis. Ultrasound Obstet Gynecol 2017; 50: 302–314. 10.1002/uog.17484 CASPubMedWeb of Science®Google Scholar 24Familiari A, Boito S, Rembouskos G, Ischia B, Accurti V, Fabietti I, Volpe P, Persico N. Cell-free DNA analysis of maternal blood in prenatal screening for chromosomal microdeletions and microduplications: a systematic review. Prenat Diagn 2021; 41: 1324–1331. 10.1002/pd.5928 CASPubMedWeb of Science®Google Scholar 25Khalil A, Sotiriadis A, Chaoui R, da Silva Costa F, D'Antonio F, Heath PT, Jones C, Malinger G, Odibo A, Prefumo F, Salomon LJ, Wood S, Ville Y. ISUOG Practice Guidelines: role of ultrasound in congenital infection. Ultrasound Obstet Gynecol 2020; 56: 128–151. 10.1002/uog.21991 CASPubMedWeb of Science®Google Scholar 26Pasquini L, Masini G, Gaini C, Franchi C, Trotta M, Dani C, Di Tommaso M. The utility of infection screening in isolated mild ventriculomegaly: an observational retrospective study on 141 fetuses. Prenat Diagn 2014; 34: 1295–300. 10.1002/pd.4470 PubMedWeb of Science®Google Scholar 27Devaseelan P, Cardwell C, Bell B, Ong S. Prognosis of isolated mild to moderate fetal cerebral ventriculomegaly: a systematic review. J Perinat Med 2010; 38: 401–409. 10.1515/jpm.2010.048 PubMedWeb of Science®Google Scholar 28Bascietto F, Liberati M, Murgano D, Buca D, Iacovelli A, Flacco ME, Manzoli L, Familiari A, Scambia G, D'Antonio F. Outcome of fetuses with congenital parvovirus B19 infection: systematic review and meta-analysis. Ultrasound Obstet Gynecol 2018; 52: 569–576. 10.1002/uog.19092 CASPubMedWeb of Science®Google Scholar 29Williamson LM, Hackett G, Rennie J, Palmer CR, Maciver C, Hadfield R, Hughes D, Jobson S, Ouwehand WH. The natural history of fetomaternal alloimmunization to the platelet-specific antigen HPA-1a (PlA1, Zwa) as determined by antenatal screening. Blood 1998; 92: 2280–2287. 10.1182/blood.V92.7.2280 CASPubMedWeb of Science®Google Scholar 30Sileo FG, Zöllner J, D'Antonio F, Islam S, Papageorghiou AT, Khalil A. Perinatal and long-term outcome of fetal intracranial hemorrhage: systematic review and meta-analysis. Ultrasound Obstet Gynecol 2022; 59: 585–595. 10.1002/uog.24766 CASPubMedWeb of Science®Google Scholar 31Di Mascio D, Sileo FG, Khalil A, Rizzo G, Persico N, Brunelli R, Giancotti A, Panici PB, Acharya G, D'Antonio F. Role of magnetic resonance imaging in fetuses with mild or moderate ventriculomegaly in the era of fetal neurosonography: systematic review and meta-analysis. Ultrasound Obstet Gynecol 2019; 54: 164–171. 10.1002/uog.20197 CASPubMedWeb of Science®Google Scholar 32Griffiths PD, Brackley K, Bradburn M, Connolly DJA, Gawne-Cain ML, Griffiths DI, Kilby MD, Mandefield L, Mooney C, Robson SC, Vollmer B, Mason G. Anatomical subgroup analysis of the MERIDIAN cohort: ventriculomegaly. Ultrasound Obstet Gynecol 2017; 50: 736–744. 10.1002/uog.17475 CASPubMedWeb of Science®Google Scholar 33 ENSO Working Group. Role of prenatal magnetic resonance imaging in fetuses with isolated mild or moderate ventriculomegaly in the era of neurosonography: international multicenter study. Ultrasound Obstet Gynecol 2020; 56: 340–347. 10.1002/uog.21974 PubMedWeb of Science®Google Scholar 34Paladini D, Malinger G, Pilu G, Timor-Trisch I, Volpe P. The MERIDIAN trial: caution is needed. Lancet 2017; 389: 2103. 10.1016/S0140-6736(17)31337-5 PubMedWeb of Science®Google Scholar 35Corroenne R, Arthuis C, Kasprian G, Mahallati H, Ville Y, Millischer Bellaiche AE, Henry C, Grevent D, Salomon LJ. Diffusion tensor imaging of fetal brain: principles, potential and limitations of promising technique. Ultrasound Obstet Gynecol 2022; 60: 470–476. 10.1002/uog.24935 CASPubMedWeb of Science®Google Scholar 36Mercier A, Eurin D, Mercier PY, Verspyck E, Marpeau L, Marret S. Isolated mild fetal cerebral ventriculomegaly: a retrospective analysis of 26 cases. Prenat Diagn 2001; 21: 589–595. 10.1002/pd.88 CASPubMedWeb of Science®Google Scholar 37Scala C, Familiari A, Pinas A, Papageorghiou AT, Bhide A, Thilaganathan B, Khalil A. Perinatal and long-term outcomes in fetuses diagnosed with isolated unilateral ventriculomegaly: systematic review and meta-analysis. Ultrasound Obstet Gynecol 2017; 49: 450–459. 10.1002/uog.15943 CASPubMedWeb of Science®Google Scholar 38Thorup E, Jensen LN, Bak GS, Ekelund CK, Greisen G, Jørgensen DS, Hellmuth SG, Wulff C, Petersen OB, Pedersen LH, Tabor A. Neurodevelopmental disorder in children believed to have isolated mild ventriculomegaly prenatally. Ultrasound Obstet Gynecol 2019; 54: 182–189. 10.1002/uog.20111 CASPubMedWeb of Science®Google Scholar 39Li QM, Liao HZ, Wang WB, Zeng SY, Qiu XS, Ke S, Xiao J, Li QH, Xia XW, Li Y. Prognostic analysis and risk factors associated with fetal ventriculomegaly. Pediatr Neurosurg 2021; 56: 407–415. 10.1159/000516378 CASPubMedWeb of Science®Google Scholar 40Baffero GM, Crovetto F, Fabietti I, Boito S, Fogliani R, Fumagalli M, Triulzi F, Mosca F, Fedele L, Persico N. Prenatal ultrasound predictors of postnatal major cerebral abnormalities in fetuses with apparently isolated mild ventriculomegaly. Prenat Diagn 2015; 35: 783–788. 10.1002/pd.4607 PubMedWeb of Science®Google Scholar 41Giorgione V, Haratz KK, Constantini S, Birnbaum R, Malinger G. Fetal cerebral ventriculomegaly: What do we tell the prospective parents? Prenat Diagn 2022; 42: 1674–1681. 10.1002/pd.6266 PubMedWeb of Science®Google Scholar 42Atad-Rapoport M, Schweiger A, Lev D, Sadan-Strul S, Malinger G, Lerman-Sagie T. Neuropsychological follow-up at school age of children with asymmetric ventricles or unilateral ventriculomegaly identified in utero. BJOG 2015; 122: 932–938. 10.1111/1471-0528.12976 CASPubMedWeb of Science®Google Scholar 43Sadan S, Malinger G, Schweiger A, Lev D, Lerman-Sagie T. Neuropsychological outcome of children with asymmetric ventricles or unilateral mild ventriculomegaly identified in utero. BJOG 2007; 114: 596–602. 10.1111/j.1471-0528.2007.01301.x CASPubMedWeb of Science®Google Scholar 44D'Antonio F, Papageorghiou A. Long-term follow-up studies are required to improve prenatal counselling. BJOG 2015; 122: 939. 10.1111/1471-0528.13089 PubMedWeb of Science®Google Scholar 45Hack M, Taylor HG, Drotar D, Schluchter M, Cartar L, Wilson-Costello D, Klein N, Friedman H, Mercuri-Minich N, Morrow M. Poor predictive validity of the Bayley Scales of Infant Development for cognitive function of extremely low birth weight children at school age. Pediatrics 2005; 116: 333–341. 10.1542/peds.2005-0173 PubMedWeb of Science®Google Scholar 46Marlow N. Measuring neurodevelopmental outcome in neonatal trials: a continuing and increasing challenge. Arch Dis Child Fetal Neonatal Ed 2013; 98: F554–8. 10.1136/archdischild-2012-302970 PubMedWeb of Science®Google Scholar 47Jelliffe-Pawlowski LL, Hansen RL. Neurodevelopmental outcome at 8 months and 4 years among infants born full-term small-for-gestational-age. J Perinatol 2004; 24: 505–514. 10.1038/sj.jp.7211111 PubMedGoogle Scholar 48Váradi V, Tóth Z, Török O, Papp Z. Heterogeneity and recurrence risk for congenital hydrocephalus (ventriculomegaly): a prospective study. Am J Med Genet 1988; 29: 305–310. 10.1002/ajmg.1320290209 CASPubMedWeb of Science®Google Scholar Volume63, Issue2February 2024Pages 153-163 ReferencesRelatedInformation