抗体
泛素连接酶
胞浆
Tau病理学
免疫疗法
受体
细胞生物学
化学
泛素
癌症研究
神经科学
生物
疾病
免疫学
医学
免疫系统
生物化学
阿尔茨海默病
病理
酶
基因
作者
Aamir S. Mukadam,Lauren V. C. Miller,Annabel E. Smith,Sophie Keeling,Marina Vaysburd,Jan Terje Andersen,Leo C. James,William A. McEwan
摘要
Abstract Background Using a variety of cell and animal model systems we demonstrate that the cytosolic antibody receptor and E3 ligase TRIM21 plays a critical role in antibody‐mediated protection against tau pathology Method Experiments with organotypic hippocampal slice cultures and in vivo studies in mouse models were conducted to study the role of TRIM21 in tau immunotherapy. Result We demonstrate that tau:antibody complexes were internalised to the cytosol of neurons, enabling TRIM21 engagement and thereby protecting against seeded aggregation. Crucially, antibody‐mediated protection against tau pathology was lost in mice lacking TRIM21 Conclusion The cytosolic compartment provides a site of immunotherapeutic protection, which can help in the design of antibody‐based therapies in neurodegenerative disease.
科研通智能强力驱动
Strongly Powered by AbleSci AI