糖酵解
细胞迁移
癌细胞
化学
细胞生长
细胞培养
基质金属蛋白酶
癌症研究
癌症
生物
细胞
分子生物学
细胞生物学
酶
生物化学
遗传学
作者
Yingying He,Dingyu Lu,Hao Cheng,Youcai Zhang,Fei Wu,Zhaohong Chen
出处
期刊:PubMed
日期:2023-11-01
卷期号:53 (6): 840-846
摘要
PPFIA4 has been reported to be associated with cancer glycolysis, but its role in esophageal cancer (EC) is unclear.To investigate the role of PPFIA4 in EC.qRT-PCR and WB were used to detect the expression of PPFIA4 in EC cells and normal cells. PPFIA4 was inhibited to detect changes in the invasion and migration ability of EC cells. WB detected the expression of cell invasion and migration marker proteins MMP-2 and MMP-9, and the kit detected changes in ATP and lactate levels in EC cells.PPFIA4 was highly expressed in EC cells. Inhibition of PPFIA4 inhibited the invasion and migration ability as well as the expression of MMP-2 and MMP-9 in EC cells, and decreased the levels of ATP and lactate in EC cells.Inhibition of PPFIA4 inhibited invasion, migration ability and glycolysis of EC cells.
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