化学
对映选择合成
催化作用
铜
有机化学
药物化学
作者
Xiaotao Zhu,Hongli Bao,Jiajia Xi
出处
期刊:Synthesis
[Georg Thieme Verlag KG]
日期:2024-01-08
被引量:2
摘要
Abstract The copper-catalyzed enantioselective radical esterification of propargylic C–H bonds with tert-butyl peroxybenzoate (TBPB) as an oxidizing agent and an oxygenated nucleophile is reported. This variant of the Kharasch–Sosnovsky oxidation allows for the asymmetric esterification of open-chain carbon radicals without excessive amounts of alkyne substrates under mild reaction conditions, achieving a one-step conversion of simple alkynes into chiral propargylic esters.
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