Circulating cytokines and risk of developing hypertension: A systematic review and meta-analysis

医学 荟萃分析 四分位数 相对风险 危险系数 血压 混淆 内科学 置信区间
作者
Elisabetta Caiazzo,Malvika Sharma,Asma O.M. Rezig,Moustafa I. Morsy,Marta Cześnikiewicz‐Guzik,Armando Ialenti,Joanna Sulicka‐Grodzicka,Pierpaolo Pellicori,Simone H. Crouch,Aletta E. Schutte,Dario Bruzzese,Pasquale Maffia,Tomasz J. Guzik
出处
期刊:Pharmacological Research [Elsevier BV]
卷期号:200: 107050-107050 被引量:13
标识
DOI:10.1016/j.phrs.2023.107050
摘要

Immune responses play a significant role in hypertension, though the importance of key inflammatory mediators remains to be defined. We used a systematic literature review and meta-analysis to study the associations between key cytokines and incident hypertension. We performed a systematic search of Pubmed/Medline, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL), for peer-reviewed studies published up to August 2022. Incident hypertension was defined as systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg and/or the use of antihypertensive medications. Random effects meta-analyses were used to calculate pooled hazard ratios (HRs)/risk ratios (RRs) and 95% confidence intervals by cytokine levels (highest vs. lowest quartile). Only IL-6 and IL-1β levels have evidence allowing for quantitative evaluation concerning the onset of hypertension. Six studies (10,406 participants, 2,932 incident cases) examined the association of IL-6 with incident hypertension. The highest versus lowest quartile of circulating IL-6 was associated with a significant HR/RR of hypertension (1.61, 95% CI: 1.00 to 2.60; I2=87%). After adjusting for potential confounders, including body mass index (BMI), HR/RR was no longer significant (HR/RR: 1.24; 95% CI, 0.96 to 1.61; I2= 56%). About IL-1β, neither the crude (HR/RR: 1.03; 95% CI, 0.60 to 1.76; n=2) nor multivariate analysis (HR/RR: 0.97, 95% CI, 0.60 to 1.56; n=2) suggested a significant association with the risk of developing hypertension. A limited number of studies suggest that higher IL-6, but not IL-1β, might be associated with the development of hypertension.
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