脱钙骨基质
数据库管理
自愈水凝胶
材料科学
骨愈合
自愈
基质骨
纳米复合材料
生物医学工程
基质(化学分析)
复合材料
高分子化学
外科
解剖
软骨
医学
放大器
替代医学
光电子学
CMOS芯片
病理
作者
Chen Chen,Zhi Li,Changlu Xu,Minjee Kang,Chung‐Sung Lee,Tara Aghaloo,Min Lee
标识
DOI:10.1002/adhm.202303592
摘要
Abstract Demineralized bone matrix (DBM) has been widely used as an allogeneic alternative to autologous bone graft for bone repair. However, more extensive use of DBM is limited due to its particulate nature after demineralization and rapid particle dispersion following irrigation, resulting in unpredictable osteoinductivity. Here, a new design of injectable hydrogel carriers for DBM that combine self‐healing ability and osteogenic properties based on the self‐assembly of guanidinylated hyaluronic acid and silica‐rich nanoclays is reported. The nanoclays serve as reversible linkages to form a dynamic hydrogel network with the guanidine moieties on the polymer chains. Gelation kinetics and mechanical properties can be controlled by altering nanoclay content in the hydrogel. The resulting hydrogel exerts self‐healing ability due to its dynamic crosslinks and well retains its overall performance with high DBM loading. The hydrogel exhibits great cytocompatibility and osteogenic effects mediated by the nanoclays. In vivo delivery of DBM using the nanocomposite hydrogel further demonstrates robust bone regeneration in a mouse calvarial defect model in comparison to DBM delivered with aqueous HA. This work suggests a promising hydrogel platform for many applications including therapeutic delivery and tissue engineering.
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