Temporal hyper-connectivity and frontal hypo-connectivity within gamma band in schizophrenia: A resting state EEG study

精神分裂症(面向对象编程) 中间性中心性 脑电图 颞叶 额叶 神经科学 心理学 听力学 精神科 医学 中心性 癫痫 数学 组合数学
作者
Chang Yuan,Xiaojuan Wang,Jingmeng Liao,Sitong Chen,Xiaoya Liu,Shuang Liu,Dong Ming
出处
期刊:Schizophrenia Research [Elsevier BV]
卷期号:264: 220-230 被引量:2
标识
DOI:10.1016/j.schres.2023.12.017
摘要

The brain network serves as the physiological foundation for information processing of the brain. Many studies have reported abnormalities of gamma oscillations in Schizophrenia. The aim of this study was to investigate the gamma-band connectivity in Schizophrenia patients. We recorded the resting state electroencephalogram (EEG) for 15 schizophrenia patients with refractory auditory hallucinations and 14 healthy controls, with eyes open and closed. The brain network was constructed based on weighted phase lag index for gamma band. Whole scalp metrics (clustering coefficient, global efficiency and local efficiency) and local region metrics (degree and betweenness centrality) in the frontal and temporal lobes were computed. Correlation analyses between network metrics and symptom scales were examined to find associations with symptom severity. Schizophrenia patients had larger global efficiency and local efficiency (p < 0.05) with eyes closed, probably representing greater brain activity and information exchange. For degree and betweenness centrality, schizophrenia patients showed an increase (p < 0.05) in the temporal lobe but a decrease (p < 0.05) in the frontal lobe with eyes closed and open, potentially account for the patients' symptoms such as hallucinations and thought disorders. Local efficiency and frontal lobe degree were positively and negatively correlated with the scales, respectively (both p < 0.05). Altered connectivity of the resting state brain network has been revealed and may be associated with the core symptoms of schizophrenia. Our study provides promising evidence for the investigation of the pathological basis of Schizophrenia and could aid in objective diagnosis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
肱二头肌完成签到,获得积分10
1秒前
2秒前
小王发布了新的文献求助10
2秒前
多情自古空余恨完成签到,获得积分10
3秒前
Qionglin完成签到,获得积分10
5秒前
Bao完成签到 ,获得积分10
6秒前
6秒前
初夏微凉发布了新的文献求助30
6秒前
7秒前
书霂完成签到,获得积分10
7秒前
优秀含羞草完成签到,获得积分10
8秒前
宓沂完成签到,获得积分10
8秒前
vivre223完成签到,获得积分10
8秒前
量子星尘发布了新的文献求助10
9秒前
受伤凌蝶完成签到,获得积分10
10秒前
wenjiejiang完成签到,获得积分10
11秒前
11秒前
zly完成签到 ,获得积分10
12秒前
12秒前
李某人完成签到,获得积分10
12秒前
13秒前
小鱼完成签到,获得积分10
14秒前
小崽总完成签到,获得积分10
14秒前
挽风完成签到,获得积分10
17秒前
17秒前
dxs发布了新的文献求助10
17秒前
苹果沛柔完成签到,获得积分10
18秒前
111完成签到 ,获得积分10
18秒前
Amon完成签到 ,获得积分10
19秒前
结实寄柔完成签到,获得积分10
20秒前
dh完成签到,获得积分0
20秒前
超帅鸭子发布了新的文献求助10
21秒前
苹果沛柔发布了新的文献求助10
22秒前
24秒前
sure完成签到 ,获得积分10
26秒前
伶俐的不尤完成签到,获得积分10
26秒前
可乐完成签到,获得积分10
27秒前
乐乐乐乐乐乐应助scinature采纳,获得10
29秒前
angrymax完成签到,获得积分10
30秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038388
求助须知:如何正确求助?哪些是违规求助? 3576106
关于积分的说明 11374447
捐赠科研通 3305798
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029