Editor—I had the privilege of interviewing John (Iain) B. Glen in his home office in Knutsford, Cheshire, UK on April 22, 2023. My goal for the interview was to preserve some of the more personal aspects of the history of propofol from the perspective of the primary inventor. 1 Glen J.B. Try, try, and try again: personal reflections on the development of propofol. Br J Anaesth. 2019; 123: 3-9 Abstract Full Text Full Text PDF PubMed Scopus (5) Google Scholar An audio recording of the interview, along with the transcript, are available in the supplementary material. In addition to personal reflections about the development of propofol, the interview covers Glen's upbringing and early days, his education and training as a veterinary physician, his path toward a career in anaesthesia-related pharmaceutical science, and his thoughts about the antecedents of success as an innovator.