败血症
血管性血友病因子
医学
ADAMTS13号
感染性休克
弥漫性血管内凝血
重症监护室
凝结
重症监护医学
血栓形成
器官功能障碍
病理生理学
严重败血症
免疫学
休克(循环)
内科学
血小板
作者
Hasam Madarati,Kanwal Singh,Taylor Sparring,Peter Andrisani,Patricia C. Liaw,Alison Fox‐Robichaud,Colin A. Kretz
出处
期刊:Shock
[Ovid Technologies (Wolters Kluwer)]
日期:2023-12-11
卷期号:61 (2): 189-196
被引量:1
标识
DOI:10.1097/shk.0000000000002291
摘要
Sepsis is defined as a life-threatening organ dysfunction caused by excessive host response to infection, and represents the most common cause of in-hospital deaths. Sepsis accounts for 30% of all critically ill patients in the intensive care unit (ICU), and has a global mortality rate of 20%. Activation of blood coagulation during sepsis and septic shock can lead to disseminated intravascular coagulation, which is characterized by microvascular thrombosis. Von Willebrand factor (VWF) and ADAMTS13 are two important regulators of blood coagulation that may be important links between sepsis and mortality in the ICU. Herein we review our current understanding of VWF and ADAMTS13 in sepsis and other critical illnesses and discuss their contribution to disease pathophysiology, their use as markers of severe illness, and potential targets for new therapeutic development.
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