DNA折纸
材料科学
纳米技术
等离子体子
癌症
癌症影像学
DNA纳米技术
DNA
光电子学
生物
遗传学
纳米结构
作者
Lintong Wu,Swati Tanwar,Gagandeep Kaur,S. K. Date,Linika Goel,Arnab Chatterjee,Patricia McGuiggan,Ishan Barman
标识
DOI:10.1002/adfm.202309929
摘要
Plasmonic nanomaterials bearing targeting ligands are of great interest for surface-enhanced Raman scattering (SERS)-based bioimaging applications. However, the practical utility of SERS-based imaging strategies has been hindered by the lack of a straightforward method to synthesize highly sensitive SERS-active nanostructures with high yield and efficiency. In this work, leveraging DNA origami principles, we report the first-in-class design of a SERS-based plasmonically coupled nanoprobe for targeted cancer imaging (SPECTRA). The nanoprobe harnesses a cancer cell targeting DNA aptamer sequence and vibrational tag with stretching frequency in the cell-silent Raman window. Through the integration of aptamer sequence specific for DU145 cells, we show the unique capabilities of SPECTRA for targeted imaging of DU145 cells. Our results demonstrate that the scalability, cost-effectiveness, and reproducibility of this method of fabrication of SERS nanoprobes can serve as a versatile platform for creating nanoprobes with broad applications in the fields of cancer biology and biomedical imaging.
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