回肠
转录组
免疫系统
疾病
间质细胞
克罗恩病
生物
免疫失调
结直肠癌
免疫学
癌症研究
医学
内科学
癌症
基因
遗传学
内分泌学
基因表达
作者
Lingjia Kong,Vladislav Pokatayev,Ariel Lefkovith,Grace T. Carter,Elizabeth A. Creasey,Chirag Krishna,Sathish Subramanian,Bharati Kochar,Orr Ashenberg,Helena Lau,Ashwin N. Ananthakrishnan,Daniel B. Graham,Jacques Deguine,Ramnik J. Xavier
出处
期刊:Immunity
[Elsevier]
日期:2023-12-01
卷期号:56 (12): 2855-2855
被引量:1
标识
DOI:10.1016/j.immuni.2023.10.017
摘要
(Immunity 56, 444–458.e1–e5; February 14, 2023) We recently became aware of an error in the clinical metadata provided in Table S1. During the aggregation of the records at the patient level, some of the columns were mistakenly sorted by age and mismatched from the patient IDs. We have now corrected this error in the article online. The datasets corresponding to sample-level and channel-level information, which were used as model covariates, are not affected, and therefore, this does not affect any of the analyses and conclusions presented in this work. We apologize for this issue. The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colonKong et al.ImmunityJanuary 30, 2023In BriefCrohn’s disease (CD) is a heterogeneous condition impacting the ileum and colon in unique ways. Here, Kong et al. define the unique epithelial, stromal, and immune characteristics of CD by generating a single-cell transcriptomic atlas of the ileum and colon and uncover novel regulators of collagen production in disease-associated fibroblasts. Full-Text PDF
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