ALPK3 Functions as a Pseudokinase

HomeCirculationVol. 148, No. 23ALPK3 Functions as a Pseudokinase No AccessResearch ArticleRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessResearch ArticleRequest AccessFull TextALPK3 Functions as a Pseudokinase Wei Feng, Julius Bogomolovas, Li Wang, Mengchen Li and Ju Chen Wei FengWei Feng Department of Medicine, University of California San Diego, La Jolla. , Julius BogomolovasJulius Bogomolovas Department of Medicine, University of California San Diego, La Jolla. , Li WangLi Wang https://orcid.org/0000-0002-6586-2571 Department of Medicine, University of California San Diego, La Jolla. , Mengchen LiMengchen Li https://orcid.org/0000-0002-5996-124X Department of Medicine, University of California San Diego, La Jolla. and Ju ChenJu Chen Correspondence to: Ju Chen, PhD, 3147 Biomedical Sciences Way, Israni Biomedical Research Facility, Room 2A14, University of California San Diego, La Jolla, CA 92093. Email E-mail Address: [email protected] https://orcid.org/0000-0001-7674-4776 Department of Medicine, University of California San Diego, La Jolla. Originally published4 Dec 2023https://doi.org/10.1161/CIRCULATIONAHA.123.065993Circulation. 2023;148:1911–1913Footnotes*W. Feng and J. Bogomolovas contributed equally.For Sources of Funding and Disclosures, see page 1913.Circulation is available at www.ahajournals.org/journal/circCorrespondence to: Ju Chen, PhD, 3147 Biomedical Sciences Way, Israni Biomedical Research Facility, Room 2A14, University of California San Diego, La Jolla, CA 92093. Email juchen@health.ucsd.eduREFERENCES1. Walsh R, Bezzina CR. ALPK3: a full spectrum cardiomyopathy gene?Eur Heart J. 2021; 42:3074–3077. doi: 10.1093/eurheartj/ehab415CrossrefMedlineGoogle Scholar2. Agarwal R, Wakimoto H, Paulo JA, Zhang Q, Reichart D, Toepfer C, Sharma A, Tai AC, Lun M, Gorham J, et al. Pathogenesis of cardiomyopathy caused by variants in ALPK3, an essential pseudokinase in the cardiomyocyte nucleus and sarcomere.Circulation. 2022; 146:1674–1693. doi: 10.1161/CIRCULATIONAHA.122.059688LinkGoogle Scholar3. McNamara JW, Parker BL, Voges HK, Mehdiabadi NR, Bolk F, Ahmad F, Chung JD, Charitakis N, Molendijk J, Zech ATL, et al. Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle.Nat Cardiovasc Res. 2023; 2:159–173. doi: 10.1038/s44161-023-00219-9CrossrefGoogle Scholar4. Kaitsuka T, Katagiri C, Beesetty P, Nakamura K, Hourani S, Tomizawa K, Kozak JA, Matsushita M. Inactivation of TRPM7 kinase activity does not impair its channel function in mice.Sci Rep. 2014; 4:5718. doi: 10.1038/srep05718CrossrefMedlineGoogle Scholar5. Kwon A, Scott S, Taujale R, Yeung W, Kochut KJ, Eyers PA, Kannan N. Tracing the origin and evolution of pseudokinases across the tree of life.Sci Signal. 2019; 12:eaav3810. doi: 10.1126/scisignal.aav3810CrossrefMedlineGoogle Scholar eLetters(0) eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate. Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page. Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetails December 5, 2023Vol 148, Issue 23 Advertisement Article Information Metrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.123.065993PMID: 38048395 Originally publishedDecember 4, 2023 KeywordsALPK3cardiomyopathyCRISPR/Cas9kinase activitypseudokinasePDF download Advertisement Subjects Cardiomyopathy