河马信号通路
生物
斑马鱼
再生(生物学)
淋巴管新生
细胞生物学
血管生成
信号转导
效应器
血管生成
癌症研究
干细胞
癌症
转移
遗传学
基因
祖细胞
作者
Sakurako Kobayashi,Andrew G. Cox,Kieran F. Harvey,Benjamin M. Hogan
标识
DOI:10.1016/j.devcel.2023.11.002
摘要
The Hippo signaling pathway regulates developmental organ growth, regeneration, and cell fate decisions. Although the role of the Hippo pathway, and its transcriptional effectors YAP and TAZ, has been well documented in many cell types and species, only recently have the roles for this pathway come to light in vascular development and disease. Experiments in mice, zebrafish, and in vitro have uncovered roles for the Hippo pathway, YAP, and TAZ in vasculogenesis, angiogenesis, and lymphangiogenesis. In addition, the Hippo pathway has been implicated in vascular cancers and cardiovascular diseases, thus identifying it as a potential therapeutic target for the treatment of these conditions. However, despite recent advances, Hippo's role in the vasculature is still underappreciated compared with its role in epithelial tissues. In this review, we appraise our current understanding of the Hippo pathway in blood and lymphatic vessel development and highlight the current knowledge gaps and opportunities for further research.
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