激进的
化学
歧化
光化学
阳离子聚合
超氧化物
光动力疗法
根本歧化
四氢生物蝶呤
辅因子
有机化学
酶
催化作用
作者
Kun‐Xu Teng,Dongsheng Zhang,Bin‐Kai Liu,Zheng‐Fei Liu,Li‐Ya Niu,Qing‐Zheng Yang
标识
DOI:10.1002/anie.202318783
摘要
We herein present an approach of photo-induced disproportionation for preparation of Type-I photodynamic agents. As a proof of concept, BODIPY-based photosensitizers were rationally designed and prepared. The photo-induced intermolecular electron transfer between homotypic chromophores leads to the disproportionation reaction, resulting in the formation of charged intermediates, cationic and anionic radicals. The cationic radicals efficiently oxidize the cellularimportant coenzyme, tetrahydrobiopterin (BH4 ), and the anionic radicals transfer electrons to oxygen to produce superoxide radicals (O2- ⋅). One of our Type-I photodynamic agents not only self-assembles in water but also effectively targets the endoplasmic reticulum. It displayed excellent photocytotoxicity even in highly hypoxic environments (2 % O2 ), with a half-maximal inhibitory concentration (IC50 ) of 0.96 μM, and demonstrated outstanding antitumor efficacy in murine models bearing HeLa tumors.
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