生物相容性材料
纳米晶
材料科学
纳米技术
工程类
生物医学工程
作者
Juanjuan Xue,Danyang Chen,Huamei Zhang,Li Xin Guo,Pengcui Li,Dan Han,Xing Guo,Qianqian Duan,Shengbo Sang
出处
期刊:ACS applied nano materials
[American Chemical Society]
日期:2024-02-05
卷期号:7 (4): 3997-4007
被引量:3
标识
DOI:10.1021/acsanm.3c05605
摘要
The low stability and high toxicity of CsPbBr3 perovskite nanocrystals (PNCs) greatly limit their application in the biological field. Here, six different CsPbBr3 PNCs were prepared by ligand-assisted reprecipitation (LARP) and hot injection using oleic acid (OA), oleamine (OAm), (3-Aminopropyl) triethoxysilane (APTES) modification and SiO2 coating, respectively. Different ligands, shells, and synthesis methods give CsPbBr3 PNCs diverse optical properties, stability, and biocompatibility. Among them, OA-OAm-APTES-CsPbBr3@SiO2 has the highest photoluminescence quantum yield (PLQY) (80.74%) and higher stability (fluorescence intensity remains 70% after 15 days in an atmospheric environment). OA-OAm-APTES-CsPbBr3@SiO2 (30 μg/mL) was cocultured with liver cancer cells for 12 h, and the survival rate was 80%, indicating high biocompatibility. Under the observation of the microplate reader, bright green fluorescence appeared in the cytoplasm, indicating that OA-OAm-APTES-CsPbBr3@SiO2 has great application potential in the field of bioimaging.
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