Systolic blood pressure is associated with abnormal alterations in brain cortical structure: Evidence from a Mendelian randomization study

血压 医学 心脏病学 孟德尔随机化 内科学 脉冲压力 遗传学 遗传变异 生物 基因 基因型
作者
Ziliang Ye,Qing Zeng,Limeng Ning,Wanzhong Huang,Qiang Su
出处
期刊:European Journal of Internal Medicine [Elsevier BV]
卷期号:120: 92-98
标识
DOI:10.1016/j.ejim.2023.10.018
摘要

Background Hypertension has been recognized as a significant risk factor for cerebrovascular diseases and cognitive decline. However, the specific impact of hypertension, systolic/diastolic blood pressure, pulse pressure (PP) and mean arterial pressure (MAP) on brain cortical structure remains unclear. Mendelian randomization (MR) provides a robust approach to investigate the causal relationship between blood pressure components and brain cortical changes. Methods In this MR study, data from large-scale genome-wide association studies for blood pressure components and neuroimaging were utilized to conduct our analyses. We leveraged genetic variants associated specifically with hypertension (122,620 cases and 332,683 controls), systolic (469,767 individuals), diastolic (490,469 individuals) blood pressure, PP (810,865 individuals) and MAP (over 1 million individuals) to evaluate their effects on brain cortex surficial area (51,665 individuals) and cortex thickness (51,665 individuals). Results Our findings revealed a significant correlation between systolic blood pressure and abnormal reduction in brain cortex surficial area (β=-1330.69, 95% confident interval [CI]: -2655.35 to -6.02, p = 0.0489); however, no significant relationship was found between systolic blood pressure and brain cortex thickness (β=-0.0078, 95% CI: -0.0178 to 0.0022, p = 0.1287). Additionally, no significant associations were observed between hypertension (β=-200.05, p = 0.6884; β=-0.0051, p = 0.1179, respectively), diastolic blood pressure (β=-460.63, p = 0.5160; β=0.0047, p = 0.2448, respectively), PP (β=1041.84, p = 0.3725; β=-0.0112, p = 0.2212, respectively), MAP (β=-18.84, p = 0.8841; β=0.0002, p = 0.7654, respectively) and both brain cortex surficial area and brain cortex thickness. Conclusion Our MR study provides evidence supporting the hypothesis that systolic blood pressure, rather than diastolic blood pressure, PP or MAP, is associated with abnormal changes in brain cortical structure.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
墨菲特发布了新的文献求助10
1秒前
YamDaamCaa应助N0V1CE采纳,获得50
1秒前
WNing完成签到,获得积分20
1秒前
小巧的虔发布了新的文献求助10
2秒前
量子星尘发布了新的文献求助10
2秒前
3秒前
Owen应助动听胜采纳,获得10
4秒前
4秒前
LISHAN应助大洁采纳,获得10
4秒前
renyi发布了新的文献求助10
5秒前
科研混子完成签到,获得积分10
6秒前
qqqqwf发布了新的文献求助20
7秒前
9秒前
福老板完成签到,获得积分20
9秒前
忆修完成签到,获得积分10
9秒前
9秒前
所所应助儒雅寒天采纳,获得10
11秒前
七七完成签到,获得积分20
11秒前
无私啤酒完成签到,获得积分10
12秒前
诸-z完成签到,获得积分10
12秒前
13秒前
动听胜完成签到,获得积分20
14秒前
我是老大应助大观天下采纳,获得10
14秒前
动听胜发布了新的文献求助10
16秒前
叶叶叶完成签到,获得积分20
17秒前
大观天下完成签到,获得积分10
19秒前
19秒前
沉静亦寒完成签到 ,获得积分10
19秒前
hetao286完成签到,获得积分10
20秒前
Skilixta完成签到,获得积分10
21秒前
newgeno2003完成签到,获得积分10
22秒前
福老板发布了新的文献求助10
22秒前
24秒前
自信河马完成签到,获得积分10
24秒前
梁林林完成签到,获得积分10
25秒前
打打应助以泪洗面奶采纳,获得10
26秒前
搜集达人应助砍柴少年采纳,获得10
27秒前
27秒前
zzzyyyuuu完成签到 ,获得积分10
27秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Toward a Combinatorial Approach for the Prediction of IgG Half-Life and Clearance 500
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969917
求助须知:如何正确求助?哪些是违规求助? 3514626
关于积分的说明 11175060
捐赠科研通 3249928
什么是DOI,文献DOI怎么找? 1795165
邀请新用户注册赠送积分活动 875617
科研通“疑难数据库(出版商)”最低求助积分说明 804891