已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Systolic blood pressure is associated with abnormal alterations in brain cortical structure: Evidence from a Mendelian randomization study

血压 医学 心脏病学 孟德尔随机化 内科学 脉冲压力 遗传学 遗传变异 生物 基因 基因型
作者
Ziliang Ye,Qing Zeng,Limeng Ning,Wanzhong Huang,Qiang Su
出处
期刊:European Journal of Internal Medicine [Elsevier BV]
卷期号:120: 92-98
标识
DOI:10.1016/j.ejim.2023.10.018
摘要

Background Hypertension has been recognized as a significant risk factor for cerebrovascular diseases and cognitive decline. However, the specific impact of hypertension, systolic/diastolic blood pressure, pulse pressure (PP) and mean arterial pressure (MAP) on brain cortical structure remains unclear. Mendelian randomization (MR) provides a robust approach to investigate the causal relationship between blood pressure components and brain cortical changes. Methods In this MR study, data from large-scale genome-wide association studies for blood pressure components and neuroimaging were utilized to conduct our analyses. We leveraged genetic variants associated specifically with hypertension (122,620 cases and 332,683 controls), systolic (469,767 individuals), diastolic (490,469 individuals) blood pressure, PP (810,865 individuals) and MAP (over 1 million individuals) to evaluate their effects on brain cortex surficial area (51,665 individuals) and cortex thickness (51,665 individuals). Results Our findings revealed a significant correlation between systolic blood pressure and abnormal reduction in brain cortex surficial area (β=-1330.69, 95% confident interval [CI]: -2655.35 to -6.02, p = 0.0489); however, no significant relationship was found between systolic blood pressure and brain cortex thickness (β=-0.0078, 95% CI: -0.0178 to 0.0022, p = 0.1287). Additionally, no significant associations were observed between hypertension (β=-200.05, p = 0.6884; β=-0.0051, p = 0.1179, respectively), diastolic blood pressure (β=-460.63, p = 0.5160; β=0.0047, p = 0.2448, respectively), PP (β=1041.84, p = 0.3725; β=-0.0112, p = 0.2212, respectively), MAP (β=-18.84, p = 0.8841; β=0.0002, p = 0.7654, respectively) and both brain cortex surficial area and brain cortex thickness. Conclusion Our MR study provides evidence supporting the hypothesis that systolic blood pressure, rather than diastolic blood pressure, PP or MAP, is associated with abnormal changes in brain cortical structure.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
白樱恋曲完成签到 ,获得积分10
2秒前
4秒前
6秒前
小昕思完成签到 ,获得积分10
8秒前
漂亮白枫发布了新的文献求助10
11秒前
11秒前
摆渡人完成签到,获得积分10
13秒前
kyfbrahha完成签到 ,获得积分10
15秒前
16秒前
摆渡人发布了新的文献求助10
17秒前
18秒前
19秒前
慕青应助guozizi采纳,获得30
20秒前
李爱国应助漂亮白枫采纳,获得10
20秒前
芯之痕发布了新的文献求助10
23秒前
fly发布了新的文献求助10
23秒前
吴昕昕完成签到,获得积分10
27秒前
guozizi发布了新的文献求助50
28秒前
31秒前
32秒前
梦璃完成签到 ,获得积分10
33秒前
田一点发布了新的文献求助10
37秒前
vin应助guozizi采纳,获得50
37秒前
38秒前
科研学术完成签到,获得积分10
38秒前
张土豆完成签到 ,获得积分10
40秒前
Doki发布了新的文献求助10
40秒前
cyy关闭了cyy文献求助
40秒前
芯之痕发布了新的文献求助100
44秒前
曲寻梅发布了新的文献求助20
45秒前
47秒前
小何HUHU完成签到,获得积分10
47秒前
aaa完成签到 ,获得积分10
47秒前
乐乐应助xiaohuangya采纳,获得10
47秒前
吾皇完成签到 ,获得积分10
49秒前
yyy完成签到 ,获得积分10
50秒前
taotao完成签到,获得积分10
52秒前
54秒前
001完成签到 ,获得积分10
55秒前
沧海云完成签到 ,获得积分10
57秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976583
求助须知:如何正确求助?哪些是违规求助? 3520659
关于积分的说明 11204399
捐赠科研通 3257298
什么是DOI,文献DOI怎么找? 1798683
邀请新用户注册赠送积分活动 877842
科研通“疑难数据库(出版商)”最低求助积分说明 806595