免疫疗法
树突状细胞
免疫系统
脂质代谢
抗原呈递
癌症免疫疗法
重编程
生物
先天免疫系统
获得性免疫系统
T细胞
细胞生物学
免疫学
癌症研究
细胞
生物化学
作者
Zhanbo Sun,Lingyun Zhang,Lixian Liu
标识
DOI:10.1016/j.biopha.2023.115574
摘要
Dendritic cells (DCs) are the most potent antigen-presenting cells in the human body. They detect and process environmental signals and communicate with T cells to bridge innate and adaptive immunity. Cell activation, function, and survival are closely associated with cellular metabolism. An increasing number of studies have revealed that lipid metabolism affects DC activation as well as innate and acquired immune responses. Combining lipid metabolic regulation with immunotherapy can strengthen the ability of antigen-presentation and T-cell activation of DCs, improve the existing anti-tumor therapy, and overcome the defects of DC-related therapies in the current stage, which has great potential in cancer therapy. This review summarizes the lipid metabolism of DCs under physiological conditions, analyzes the role of reprogramming the lipid metabolism of DCs in tumor immune regulation, and discusses potential immunotherapeutic strategies.
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