肠促胰岛素
十二指肠
激素
2型糖尿病
烧蚀
内科学
内分泌学
光敏剂
胰岛素
医学
糖尿病
胃肠病学
化学
有机化学
作者
Sang‐Hee Lee,Moon Jae Chung,Moon Bae Ahn,Hyun Jin Park,Eun Kyung Wang,Taeeun Guon,Hyun Jung Kee,Cheol Ryong Ku,Kun Na
出处
期刊:Biomaterials
[Elsevier]
日期:2023-11-01
卷期号:302: 122336-122336
被引量:1
标识
DOI:10.1016/j.biomaterials.2023.122336
摘要
Duodenal ablation improves glycaemic control and weight loss, so it has been applied using hydrothermal catheters in obese and type 2 diabetes patients, indicating similar mechanisms and therapeutic effects as bariatric surgeries. Endoscopic photodynamic therapy is an innovative procedure that easily accessible to endocrine or gastrointestinal organs, so it is critical for the sprayed photosensitizer (PS) to long-term interact with target tissues for enhancing its effects. Surfactant-like PS was more stable in a wide range of pH and 2.8-fold more retained in the duodenum at 1 h than hydrophilic PS due to its amphiphilic property. Endoscopic duodenal ablation using surfactant-like PS was performed in high fat diet induced rat models, demonstrating body weight loss, enhanced insulin sensitivity, and modulation of incretin hormones. Locoregional ablation of duodenum could affect the profiles of overall intestinal cells secreting meal-stimulated hormones and further the systemic glucose and lipid metabolism, regarding gut-brain axis. Our strategy suggests a potential for a treatment of minimally invasive bariatric and metabolic therapy if accompanied by detailed clinical trials.
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