Indoor Environmental Exposures and Their Relationship to Allergic Diseases

Cockroach, dust mite, cat, dog, mouse, and molds are major indoor allergens that have been associated with the development of allergic diseases and disease morbidity in allergen-sensitized individuals. Physical characteristics, such as allergen particle size, hydrophobicity, and charge, can determine an allergen’s propensity to become airborne, location of respiratory tract penetration, and ability to elicit IgE responses in genetically predisposed individuals. Standardization and recent advancements in indoor allergen assessment serve to identify sources and distribution of allergens in a patient’s home and public environment, inform public policy, and monitor the efficacy of allergen avoidance and therapeutics. Allergen exposure interventions have yielded mixed results with current US and international asthma guidelines differing on recommendations. A pragmatic, patient-centered approach to allergen avoidance includes: (1) tailoring intervention to the patient’s sensitization and exposure status, (2) using a rigorous multifaceted intervention strategy to reduce allergen exposure as much as possible, and (3) beginning the intervention as soon as the patient is diagnosed. Further research into the risks/benefits of early allergen exposure, rapid and affordable in-home allergen assessment, and best practices for environmental control measures for asthma is needed. Cockroach, dust mite, cat, dog, mouse, and molds are major indoor allergens that have been associated with the development of allergic diseases and disease morbidity in allergen-sensitized individuals. Physical characteristics, such as allergen particle size, hydrophobicity, and charge, can determine an allergen’s propensity to become airborne, location of respiratory tract penetration, and ability to elicit IgE responses in genetically predisposed individuals. Standardization and recent advancements in indoor allergen assessment serve to identify sources and distribution of allergens in a patient’s home and public environment, inform public policy, and monitor the efficacy of allergen avoidance and therapeutics. Allergen exposure interventions have yielded mixed results with current US and international asthma guidelines differing on recommendations. A pragmatic, patient-centered approach to allergen avoidance includes: (1) tailoring intervention to the patient’s sensitization and exposure status, (2) using a rigorous multifaceted intervention strategy to reduce allergen exposure as much as possible, and (3) beginning the intervention as soon as the patient is diagnosed. Further research into the risks/benefits of early allergen exposure, rapid and affordable in-home allergen assessment, and best practices for environmental control measures for asthma is needed. Advances in the Assessment and Management of Allergic SensitizationThe Journal of Allergy and Clinical Immunology: In PracticeVol. 11Issue 10PreviewApproximately 100 years before the discovery of IgE, Charles Blackley1 described the use of scratch testing to identify pollens responsible for symptoms of hay fever, and in 1911, Robert Cooke introduced the use of intradermal testing.2 Today, modifications of the scratch and intradermal tests, the skin prick test and the skin puncture test, provide the most frequently used tests by allergists to identify allergen-specific IgE sensitivity. Lewis and Grant introduced the prick skin test in 1926, and Morrow Brown proposed the skin puncture test in 1981, both of which provided better sensitivity and reproducibility than the earlier scratch test. Full-Text PDF Indoor Environmental Exposures and Their Relationship to Allergic DiseasesThe Journal of Allergy and Clinical Immunology: In PracticeVol. 11Issue 10Preview Full-Text PDF