Controversies in Allergy: Are Biologic Treatment Responses in Severe Asthma the Same in Adults and Children?

The availability of biologic agents for patients with severe asthma has increased dramatically over the last several decades. The absence of direct head-to-head comparative data and relative lack of biomarkers to predict response can make it difficult to choose the right biologic medication for a given patient. Selecting a biologic agent for the pediatric population presents further challenges due to more limited approved biologic agents and fewer clinical trials in children. In addition, the outcome data that are currently available suggest that treatment responses for a given biologic may be different between adult and pediatric patients. To better understand this possible difference in treatment response, this review focuses on the available efficacy data for biologics evaluated in adult and pediatric patients with severe asthma in addition to other considerations when choosing a biologic agent. Finally, this review discusses how asthma phenotypes differ across age groups and their contributions to the responses to biologic treatment across age groups. The availability of biologic agents for patients with severe asthma has increased dramatically over the last several decades. The absence of direct head-to-head comparative data and relative lack of biomarkers to predict response can make it difficult to choose the right biologic medication for a given patient. Selecting a biologic agent for the pediatric population presents further challenges due to more limited approved biologic agents and fewer clinical trials in children. In addition, the outcome data that are currently available suggest that treatment responses for a given biologic may be different between adult and pediatric patients. To better understand this possible difference in treatment response, this review focuses on the available efficacy data for biologics evaluated in adult and pediatric patients with severe asthma in addition to other considerations when choosing a biologic agent. Finally, this review discusses how asthma phenotypes differ across age groups and their contributions to the responses to biologic treatment across age groups. How Has the Biologic Revolution Improved Patient Care?The Journal of Allergy and Clinical Immunology: In PracticeVol. 11Issue 9PreviewThe development, approval, and use of the 6 biologics for treatment of allergic and immunologic diseases have revolutionized the holistic effectiveness of care of many affected patients. Therapeutic guidance on the use of these biologics has come largely from randomized clinical trials necessary for licensing procedures. These clinical trials have necessary recruitment restrictions, which limit the applicability of findings to patients seen in practice. However, an ever-expanding clinical experience from registries and real-life trials provides new knowledge that more directly translates to the “typical” patient seen by clinicians. Full-Text PDF