Revisiting Licorice as a functional food in the management of neurological disorders: Bench to trend

甘草苷元 神经保护 异甘草素 神经药理学 医学 药理学 5-羟色胺能 甘草苷 多巴胺能 传统医学 神经科学 心理学 多巴胺 替代医学 血清素 内科学 病理 受体
作者
Ruchi Sharma,Rajeev K. Singla,Subhadip Banerjee,Rohit Sharma
出处
期刊:Neuroscience & Biobehavioral Reviews [Elsevier BV]
卷期号:155: 105452-105452 被引量:25
标识
DOI:10.1016/j.neubiorev.2023.105452
摘要

Traditional and scientific evidence attribute numerous bioactivities of Licorice (Glycyrrhiza glabra Linn.) in aging-related disorders. In this state-of-art review, an extensive search in several databases was conducted to collect all relevant literature and comprehensively analyze Licorice's pharmacological attributes, neuroprotective properties, safety, and its mechanistic role in treating various neurological conditions. Network pharmacology was employed for the first time exploring the mechanistic role of Licorice in neurological disorders. Its neuroprotective role is attributed to phytoconstituents, including liquiritin, glycyrrhizic acid, liquiritigenin, glabridin, 18ß-glycyrrhetinic acid, quercetin, isoliquiritigenin, paratocarpin B, glycyglabrone, and hispaglabridin B, as evident from in vitro and in vivo studies. Network pharmacology analysis reveals that these compounds protect against long-term depression, aging-associated diseases, Alzheimer's disease, and other addictions through interactions with cholinergic, dopaminergic, and serotonergic proteins, validated in animal studies only. Future clinical trials are warranted as Licorice administration has a limiting factor of mild hypertension and hypokalemia. Hopefully, scientific updates on Licorice will propagate a paradigm shift in medicine, research propagation, and development of the central nervous system phytopharmaceuticals.
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