代谢组学
医学
粪便
内科学
木犀草素
病例对照研究
人体测量学
胃肠病学
生理学
食品科学
生物
生物信息学
生物化学
古生物学
抗氧化剂
槲皮素
作者
Wenli Cheng,Xiao Lin,Tingting Wang,Xiaohui Zhang,Fang Xu,Li Wang,Min Wang,Meng Zhang,Tao Xia,Daoming Zhang,Shiqing Qian,Wanshui Yang,Anla Hu,Min Moon Tang,Xiangpeng Hu,Yalei Wang,Qihong Zhao
标识
DOI:10.1080/09637486.2023.2279916
摘要
Preventing the progression of gastric precancerous lesions (GPLs) can reduce the morbidity and mortality of gastric cancer (GC). The preventive effect of a plant-based diet on cancers has been widely recognised. In this case–control study, 1,130 subjects were included using 1:1 propensity score matching for age and sex. Dietary habits, anthropometry and sample collection were conducted using standard and effective methods. Plant-based diet indices (PDIs) were calculated using a previously reported method. Faecal samples were analysed by untargeted metabolomics. Our study found that adherence to a healthy plant-based diet was inversely associated with the occurrence of GPLs. Metabolomic analysis identified six different metabolites correlated with GPLs, among which luteolin-related metabolites may be used as biomarkers of the association between PDIs and GPLs. In addition, the difference in N-acyl amides found in PDIs needs further verification. Our findings suggest that a healthy plant-based diet may have a protective effect against GPLs.
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