免疫系统
腺癌
免疫疗法
癌症研究
子宫颈
转录组
肿瘤微环境
生物
医学
免疫学
病理
癌症
内科学
基因
生物化学
基因表达
作者
Hui Zhang,Chunhua Liu,Xiaoqian Zhai,Qianqian Zhang,Yao Zhou,Huang Hu,Mingde Ding,Qiang Shi,Yan Liu,Ying Tang,Guanghai Liu,Hongmei Wang
标识
DOI:10.1016/j.intimp.2023.110907
摘要
Minimal deviation adenocarcinoma (MDA) of the uterine cervix, also referred to as malignant adenoma, is a rare subtype of cervical adenocarcinoma that exhibits histological characteristics resembling those of benign tumors, resulting in a low diagnostic rate and a lack of effective treatment options. The transcriptomic features of MDA at the single-cell resolution and within the tumor microenvironment (TME) remain unclear. In this study, we conducted single-cell transcriptomic analyses of MDA samples (Ca) and adjacent normal tissues (PCa). The present study reveals the prevalence of dendritic cells (DCs) and T cells in the carcinoma (Ca) of mammary ductal adenocarcinoma (MDA), with DCs undergoing significant metabolic reprogramming and immune stress. Additionally, our findings demonstrate the crucial involvement of DCs and T cells in the pathogenesis and metastatic progression of MDA, as evidenced by single-cell transcriptomic profiling of MDA and HPV samples. This resource provides a more profound understanding of the indolent nature of MDA and may prove useful in the development of MDA immunotherapy.
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