果聚糖
炎症性肠病
小檗碱
结肠炎
益生元
溃疡性结肠炎
化学
微生物学
刺激
肠道菌群
药理学
医学
生物
免疫学
生物化学
内科学
疾病
蔗糖
作者
Hongyu Li,Wenna Yang,Xiong-Zhi Wu,Luyao Tian,Weimei Zhang,Hongyue Tian,Liang Xu,Luqi Huang,Lanping Guo,Xia Li,Wenyuan Gao
标识
DOI:10.1016/j.ijbiomac.2023.127987
摘要
Inflammatory bowel disease (IBD) can cause intestinal microbial imbalance and aggravate intestinal inflammation. Mixed fructan is more easily fermented by colonic microorganisms and can be used as colonic drug delivery materials. Here, we constructed a mixed fructan based nanoparticle with dual targeted stimulation of pH and intestinal flora to effectively deliver berberine for the treatment of ulcerative colitis (UC). The complex of fructan based nanoparticle and berberine (BBRNPs) significantly ameliorated the inflammatory response of sodium dextran sulfate (DSS)-induced colitis in mice by inhibiting the activation of NF-κB/STAT-3 pathway and increasing tight junction protein expression in vivo. Importantly, BBRNPs improved the responsiveness of colitis microbiome and effectively regulated the relative homeostasis of harmful flora Enterobacteriaceae and Escherichia-shigolla, and beneficial flora Ruminococcaceae and Akkermansiaceae. This study provides a promising strategy for the effective treatment of UC and expands the application of branched fructan in pharmaceutics.
科研通智能强力驱动
Strongly Powered by AbleSci AI