Prognostic significance of plasma S1P in acute intracerebral hemorrhage: A prospective cohort study

医学 改良兰金量表 前瞻性队列研究 内科学 置信区间 脑出血 接收机工作特性 优势比 单变量分析 队列 格拉斯哥昏迷指数 多元分析 胃肠病学 外科 缺血性中风 蛛网膜下腔出血 缺血
作者
Zefan Wang,Jian Xu,Shengdong Zou,Ziyin Chen,Shuangyong Dong,Keyi Wang
出处
期刊:Clinica Chimica Acta [Elsevier BV]
卷期号:551: 117585-117585 被引量:2
标识
DOI:10.1016/j.cca.2023.117585
摘要

Sphingosine-1-phosphate (S1P) may regulate neuroinflammatory immunity and blood–brain barrier integrity. This study was designed to assess the prognostic role of plasma S1P in intracerebral hemorrhage (ICH). In this prospective cohort study, plasma S1P levels were measured in 51 controls, at admission in 114 ICH patients and at days 1, 3, 5 and 7 in 51 of all patients. Univariate analysis and multivariate analysis were sequentially used to investigate severity correlation and prognosis association. Plasma S1P levels were significantly elevated at admission, peaked at day 5, and declined at day 7, which were significantly higher during 7 days than those of controls (all P < 0.001). Areas under receiver operating characteristic curve (AUCs) of plasma S1P levels insignificant differed among all time points (all P > 0.05). Admission plasma S1P levels, in close correlation with National Institutes of Health Stroke Scale (NIHSS) scores [β, 7.661; 95 % confidence interval (CI), 4.893–10.399; P < 0.001] and hematoma volume (β, 1.285; 95 % CI, 0.348–2.230; P < 0.001), independently predicted 3-month poor prognosis (modified Rankin Scale scores of 3–6) (odds ratio, 3.184; 95 % CI, 1.057–9.597; P = 0.040). Admission plasma S1P levels had AUC of 0.799 (95 % CI, 0.713–0.868) for prognosis prediction. The levels > 240.4 ng/ml distinguished risk of poor prognosis with the maximum Youden index of 0.518. Prediction model integrating NIHSS scores, hematoma volume and admission plasma S1P levels had substantially higher prognostic predictive ability than NIHSS scores (P = 0.023), but not than hematoma volume (P = 0.061). There is a significant elevation of plasma S1P levels during early period after ICH, which were independently related to severity and poor prognosis. Thus, plasma S1P may be a potential prognostic biomarker of ICH.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
唐藏今完成签到,获得积分10
刚刚
3秒前
orixero应助耍酷问兰采纳,获得10
4秒前
4秒前
zriverm发布了新的文献求助10
4秒前
量子星尘发布了新的文献求助10
4秒前
希望天下0贩的0应助方格采纳,获得10
5秒前
leslie驳回了归尘应助
6秒前
Wl发布了新的文献求助10
7秒前
Lucas应助何1采纳,获得10
8秒前
小仙女212发布了新的文献求助10
9秒前
10秒前
c_123发布了新的文献求助10
10秒前
10秒前
Lorain完成签到,获得积分10
11秒前
12秒前
12秒前
13秒前
耍酷问兰发布了新的文献求助10
15秒前
15秒前
Wl关注了科研通微信公众号
15秒前
15秒前
周声声发布了新的文献求助10
17秒前
孙亦沈发布了新的文献求助10
17秒前
Lucas应助肖肖采纳,获得10
18秒前
Liufgui应助MTRQ采纳,获得10
19秒前
19秒前
南瓜气气发布了新的文献求助30
20秒前
22秒前
23秒前
钮卿发布了新的文献求助10
23秒前
YJ888发布了新的文献求助10
24秒前
欣喜沛芹发布了新的文献求助10
25秒前
25秒前
静默完成签到 ,获得积分10
25秒前
26秒前
华仔应助大罗采纳,获得10
26秒前
wonhui发布了新的文献求助10
26秒前
相信未来完成签到,获得积分0
26秒前
天天快乐应助科研通管家采纳,获得10
27秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989069
求助须知:如何正确求助?哪些是违规求助? 3531351
关于积分的说明 11253589
捐赠科研通 3269939
什么是DOI,文献DOI怎么找? 1804851
邀请新用户注册赠送积分活动 882074
科研通“疑难数据库(出版商)”最低求助积分说明 809073