突变体
计算机科学
软件
计算生物学
化学
生物
生物化学
程序设计语言
基因
出处
期刊:Methods in molecular biology
日期:2024-01-01
卷期号:: 139-147
标识
DOI:10.1007/978-1-0716-3985-6_9
摘要
Protein-protein binding affinity prediction is important for understanding complex biochemical pathways and to uncover protein interaction networks. Quantitative estimation of the binding affinity changes caused by mutations can provide critical information for protein function annotation and genetic disease diagnoses. The binding free energies of protein-protein complexes can be predicted using several computational tools. This chapter is a summary of software developed for the prediction of binding free energies for protein-protein complexes and their mutants.
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