Antibacterial Indole‐diterpenoid Alkaloids from the Marine Fungus Penicillium sp. ZYX‐Z‐718

Two new indole‐diterpenoids, penpaxilloids F and G (1 and 2), along with 11 known analogues (3−13), were isolated from the marine fungus Penicillium sp. ZYX‐Z‐718. The structures of the new compounds were identified by extensive spectroscopic analyses including HR‐ESI‐MS, UV, and NMR, as well as theoretical NMR chemical shifts and ECD calculations. Compounds 6 and 10 showed antibacterial activity against Gram‐positive bacteria including Staphylococcus aureus, Bacillus subtilis, and MRSA with MIC values ranging from 16.0 to 32.0 μg/mL.