Deep learning-based low-light image enhancement (LLIE) is a task of leveraging deep neural networks to enhance the image illumination while keeping the image content unchanged. From the perspective of training data, existing methods complete the LLIE task driven by one of the following three data types: paired data, unpaired data and zero-reference data. Each type of these data-driven methods has its own advantages, e.g., zero-reference data-based methods have very low requirements on training data and can meet the human needs in many scenarios. In this paper, we leverage pure Gaussian noise to complete the LLIE task, which further reduces the requirements for training data in LLIE tasks and can be used as another alternative in practical use. Specifically, we propose Noise SElf-Regression (NoiSER) without access to any task-related data, simply learns a convolutional neural network equipped with an instance-normalization layer by taking a random noise image, N(0,σ