声动力疗法
纳米载体
化疗
癌症
生物相容性
医学
结直肠癌
癌症研究
纳米技术
纳米颗粒
材料科学
内科学
病理
替代医学
冶金
作者
Yun Zhou,Yueyang Gao,Nannan Yao,Guozhi Lu,Chuyu Dong,Kexin Wang,Junfeng Zhang,Jing Sun,Ke Li,Xue‐Ping Li
标识
DOI:10.3389/fbioe.2024.1439883
摘要
Most colon cancer patients are diagnosed at an advanced stage, with a grim prognosis. In clinical, various combination therapies have been employed to enhance the efficacy of colon cancer treatment. The essence of combined treatment is the judicious selection and combination of various treatment units. Phototherapy (PT), sonodynamic therapy (SDT), and chemotherapy are treatment modalities that rely on the active molecules to treat tumors, and have been demonstrated to synergistically enhance tumor treatment efficacy. However, the differences in the metabolism of active molecules and hypoxic microenvironment of tumors have limited the synergistic effects of the aforementioned methods. To address this significant issue, in this study, we utilized polydopamine (PDA) as the encapsulated material to form a rigid shell that contains the therapeutic molecules IR-780 and methotrexate (MTX) on the surface of perfluorohexane (PFH) microdroplets through self-assembling method to develop an SDT/chemotherapy/PT combined nanoparticles (SCP NPs). Transmission electron microscopy (TEM) revealed that the nanoparticles exhibited a hollow shell structure, with an average size of approximately 100 nm. SCP NPs have excellent stability and biocompatibility in both
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