化学
羧酸
组合化学
化学合成
立体化学
生物化学
体外
作者
Lianru Chen,Bin Wang,Hongming Li,Jianming Mao,Zhibin Liang,Ya Chen,Mingyang Yu,Yuxia Liu,Zhengkai Liao,Yuanqian Yang,Xiaojing Wu,Sheng Wang,Yonghong Yang,Ruojing Xiang,Luyong Zhang,Zheng Li
标识
DOI:10.1016/j.ejmech.2024.116705
摘要
Histologic spectrum studies in patients revealed fatty acid binding proteins 1 (FABP1) as a potential new target for the treatment of metabolic associated fatty liver disease. However, there is no FABP1 inhibitor has been reported except the first-in-class FABP1 inhibitor bearing acid moiety reported by our laboratory. Herein, we firstly report the structure-activity relationship of novel non-carboxylic acid FABP1 inhibitors, which resulted in the identification of the potent and selective FABP1 inhibitor 30. The IC
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