毒物
微生物群
基因组
肠道菌群
肠道微生物群
生物
生理学
失调
粪便
甲基汞
脐带血
动物
生态学
医学
免疫学
生物累积
毒性
生物信息学
内科学
遗传学
基因
作者
Kelsey N. Thompson,Youssef Oulhote,Pál Weihe,Jeremy E. Wilkinson,Siyuan Ma,Zhong Huang,Junhua Li,Karsten Kristiansen,Curtis Huttenhower,Philippe Grandjean
标识
DOI:10.1021/acs.est.2c03185
摘要
Emerging experimental evidence indicates that toxicant-induced alterations in gut microbiota composition and activity may affect host homeostasis. However, data from human studies are scarce; to our knowledge, no previous studies have quantified the association of lifetime exposure to environmental chemicals, across multiple time points, with the composition of the adult gut microbiome. Here we studied 124 individuals born in the Faroe Islands in 1986-1987 who were followed approximately every seven years from birth through age 28 years. Organochlorine compounds, including polychlorinated biphenyls (PCBs) and pesticides, perfluoroalkyl substances (PFAS), and mercury (Hg), were measured in cord blood and longitudinally in participants' blood. At age 28, the gut microbiome was assessed using shotgun metagenomic sequencing. Historical contaminant exposures had little direct effect on the adult gut microbiome, while a small number of fastidious anaerobes were weakly linked to recent PFAS/PFOS exposures at age 28. In this cohort, our findings suggest no lasting effects of early life exposures on adult gut microbial composition, but proximal exposures may contribute to gut microbiome alterations. The methods developed and used for this investigation may help in future identification of small but lasting impacts of environmental toxicant exposure on the gut microbiome.
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