Bone Repair In article number 2202044, Jiayong Dai, Jianxun Ding, Huanghao Yang, and co-workers develop an osteoimmunity-regulating biomimetically hierarchical scaffold to improve large-scale bone-defect regene ration through alleviating inflammation, enhancing neovascularization, stimulating osteogenesis, and inhibiting osteoclasts, facilitating the balance of the immune system and bone metabolism and augmenting bone repair.