Tumor microenvironment responsive theranostic agent for enhanced chemo/chemodynamic/photothermal therapy

光热治疗 肿瘤微环境 阿霉素 吲哚青绿 活性氧 谷胱甘肽 化学 癌症研究 化疗 肿瘤缺氧 盐酸阿霉素 放射治疗 医学 材料科学 纳米技术 病理 生物化学 肿瘤细胞 内科学
作者
Jinxia Wang,Wenyan Kong,Hansong Jin,Chunlin Li,Qian Luo,Yu Luo,Chunping Yuan,Jie Lü,Lei Zhang,Xijian Liu
出处
期刊:Colloids and Surfaces B: Biointerfaces [Elsevier BV]
卷期号:218: 112750-112750 被引量:16
标识
DOI:10.1016/j.colsurfb.2022.112750
摘要

The specific characteristics of the tumor microenvironment (TME) and monotherapy always lead to poor therapy effects for tumors. Hereby, we have developed a smart multifunctional theranostic agent-SSMID (Se@SiO2@MnO2-ICG/DOX) nanocomposites (NCs) that could intelligently respond to the TME for enhanced chemotherapy/photothermal/chemodynamic therapy guided by magnetic resonance imaging (MRI). The SSMID NCs were composed of indocyanine green (ICG) and doxorubicin hydrochloride (DOX) co-loaded porous Se@SiO2 @MnO2. Under the specific conditions of the TME (slightly acidic, H2O2 and GSH overexpression), the MnO2 NPs were specifically decomposed and then SSMID released Mn2+, DOX and Se, which played roles in chemodynamic therapy (CDT), chemotherapy, protecting normal tissues and inhibiting tumor cells by modulating reactive oxygen species (ROS), respectively. MnO2 reacted with glutathione (GSH) and H2O2 to generate O2 and Mn2+, which alleviated tumor hypoxia to improve chemotherapy and depleted GSH to enhance oxidative stress for chemodynamic therapy. More importantly, SSMID NCs could simultaneously exert the photothermal therapy (PTT) effect with near-infrared laser irradiation and promote the release of Mn2+ and DOX to achieve enhanced chemotherapy/chemodynamic therapy. In addition, the released Mn2+ could be used as a T1-weighted MRI contrast agent to monitor tumor location. The SSMID NCs exhibited a pronounced tumor growth inhibitory effect and promising biological safety, which develop a new method to rationally design nano-theranostic agents with enhanced performance for anti-tumor.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
淡烟流水发布了新的文献求助10
2秒前
2秒前
小李发布了新的文献求助30
3秒前
汉堡包应助明芬采纳,获得30
3秒前
爆米花应助彭栋采纳,获得10
3秒前
4秒前
4秒前
MeiyanZou完成签到 ,获得积分10
4秒前
7秒前
7秒前
潇湘雪月发布了新的文献求助10
8秒前
8秒前
8秒前
9秒前
感动黄豆发布了新的文献求助10
9秒前
hhhblabla应助东方红采纳,获得10
11秒前
Poker应助sb采纳,获得10
12秒前
Ginger发布了新的文献求助10
12秒前
吃骨头的猫完成签到,获得积分10
12秒前
小李完成签到,获得积分10
12秒前
12秒前
13秒前
明芬发布了新的文献求助30
15秒前
15秒前
Smile完成签到,获得积分10
15秒前
Chaoe完成签到,获得积分10
18秒前
建国发布了新的文献求助10
19秒前
闪闪w发布了新的文献求助10
22秒前
淡烟流水完成签到,获得积分10
22秒前
俏皮芷蕊完成签到,获得积分10
23秒前
完美世界应助忐忑的阑香采纳,获得10
23秒前
华仔应助兴奋千兰采纳,获得10
28秒前
Ginger完成签到,获得积分10
29秒前
潇湘雪月发布了新的文献求助10
32秒前
科研通AI5应助科研通管家采纳,获得10
34秒前
34秒前
佳琳有乐完成签到,获得积分10
34秒前
34秒前
小蘑菇应助科研通管家采纳,获得10
34秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989115
求助须知:如何正确求助?哪些是违规求助? 3531367
关于积分的说明 11253688
捐赠科研通 3269986
什么是DOI,文献DOI怎么找? 1804868
邀请新用户注册赠送积分活动 882078
科研通“疑难数据库(出版商)”最低求助积分说明 809105