Iodine/TBHP-Mediated One-Pot Multicomponent Protocol for Tandem C–N and C–S Bond Formation To Access Sulfenylimidazo[1,5-a]pyridines via C–H Functionalization

A mild and simple protocol has been established for the formation of sulfenylated imidazo[1,5-a]pyridines. This is a metal-free iodine/TBHP-mediated one-pot multicomponent reaction, which follows C–H functionalization of the imidazo[1,5-a]pyridine skeleton formed during the reaction and its subsequent sulfenylation in the same step to offer sulfenylated imidazo[1,5-a]pyridines in good to high yields. The extension and applications of this method have also been demonstrated.