Casiopeinas® third generation, with indomethacin: synthesis, characterization, DFT studies, antiproliferative activity, and nanoencapsulation

Seven new 3rd generation Casiopeinas® are presented with the indomethacin ligand that improves their antiproliferative activity. A chitosan–polyacrylamide nanogel presents good encapsulation and release properties for the more efficient compound.