合成子
废止
化学
催化作用
路易斯酸
药物化学
基础(拓扑)
立体化学
有机化学
数学
数学分析
作者
Dongqiu Li,Jiale Wu,Lulu Yang,Shuangshuang Cai,Yuhai Tang,Yang Li,Silong Xu
标识
DOI:10.1021/acs.orglett.4c03842
摘要
Herein, we report a DMAP-catalyzed [4 + 2] annulation reaction of hex-5-en-2-ynoates 1 with electron-poor alkenes 2, which affords exocyclic olefinic cyclohexenes 3 in good yields and excellent regio-, diastereo-, and E/Z selectivities. Distinguished from previous allenoate- or alkynoate-based substrates, hex-5-en-2-ynoates 1 use the β- and ε-carbons for the bond formation, presenting new and regiodivergent C4 synthons for Lewis base-catalyzed annulations.
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