Effect of Buspirone on Upper Gastrointestinal Disorders of Gut–Brain Interaction: A Systematic Review and Meta-analysis

医学 丁螺环酮 荟萃分析 生物信息学 内科学 血清素 受体 生物
作者
Zahra Mohamedali,Gehanjali Amarasinghe,Christopher W. P. Hopkins,Calum D. Moulton
出处
期刊:Journal of Neurogastroenterology and Motility [The Korean Society of Neurogastroenterology and Motility]
卷期号:31 (1): 18-27
标识
DOI:10.5056/jnm24115
摘要

Buspirone shows promise in treating disorders of gut-brain interaction (DGBIs), particularly functional dyspepsia. However, findings have been mixed. We systematically searched for prospective studies testing buspirone for any upper gastrointestinal DGBI in 4 databases (Cochrane, PubMed, Scopus, and PsycInfo). The primary outcome was any validated measure of gastrointestinal symptoms. Anxiety, depression and adverse events were secondary outcomes. For randomized controlled trials (RCTs), we performed random-effects meta-analysis of the standardized mean difference (SMD) in post-treatment scores between buspirone and control groups. Risk of bias in RCTs was assessed using the Cochrane Common Mental Disorders Depression Anxiety and Neurosis Group (CCDAN) scale. Ten studies (n = 283) met inclusion criteria, comprising 5 RCTs, 1 N-of-1 trial, 1 cohort, 1 case series, and 2 case reports. Tolerability of buspirone was good. In meta-analysis, buspirone produced a non-significant improvement in functional dyspepsia/gastroparesis symptoms compared to placebo (SMD = -0.14; 95% CI, -0.44 to 0.17; We found that buspirone did not improve functional dyspepsia symptoms more than placebo, though studies were small. Buspirone showed benefit for bloating severity, albeit based on few studies. Larger and longer trials of buspirone, targeting more defined groups such as patients with bloating, are warranted.

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