放射基因组学
无线电技术
嫌色细胞
清除单元格
肾细胞癌
分级(工程)
嗜酸细胞瘤
单核苷酸多态性
生物
计算生物学
医学
病理
基因型
基因
放射科
遗传学
生态学
作者
Abeer J. Alhussaini,Abirami Veluchamy,Adel Jawli,Neil Kernohan,Benjie Tang,Nicholette D. Palmer,J. Douglas Steele,Ghulam Nabi
标识
DOI:10.3390/ijms252312512
摘要
RO and ChRCC are kidney tumours with overlapping characteristics, making differentiation between them challenging. The objective of this research is to create a radiogenomics map by correlating radiomic features to molecular phenotypes in ChRCC and RO, using resection as the gold standard. Fourteen patients (6 RO and 8 ChRCC) were included in the prospective study. A total of 1,875 radiomic features were extracted from CT scans, alongside 632 cytobands containing 16,303 genes from the genomic data. Feature selection algorithms applied to the radiomic features resulted in 13 key features. From the genomic data, 24 cytobands highly correlated with histology were selected and cross-correlated with the radiomic features. The analysis identified four radiomic features that were strongly associated with seven genomic features. These findings demonstrate the potential of integrating radiomic and genomic data to enhance the differential diagnosis of RO and ChRCC, paving the way for more precise and non-invasive diagnostic tools in clinical practice.
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