体内
2019年冠状病毒病(COVID-19)
药物开发
肺
生物
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
干细胞
2019-20冠状病毒爆发
疾病
计算生物学
病毒学
药品
爆发
免疫学
医学
传染病(医学专业)
病理
细胞生物学
药理学
生物技术
内科学
作者
Toka A. Ahmed,Bassant Eldaly,Shadwa Eldosuky,Hoda Elkhenany,Azza M. El-Derby,Muhamed F. Elshazly,Nagwa El‐Badri
标识
DOI:10.1186/s13287-023-03341-4
摘要
Abstract Millions of people have been affected ever since the emergence of the corona virus disease of 2019 (COVID-19) outbreak, leading to an urgent need for antiviral drug and vaccine development. Current experimentation on traditional two-dimensional culture (2D) fails to accurately mimic the in vivo microenvironment for the disease, while in vivo animal model testing does not faithfully replicate human COVID-19 infection. Human-based three-dimensional (3D) cell culture models such as spheroids, organoids, and organ-on-a-chip present a promising solution to these challenges. In this report, we review the recent 3D in vitro lung models used in COVID-19 infection and drug screening studies and highlight the most common types of natural and synthetic polymers used to generate 3D lung models.
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