卡铂
黑色素瘤
医学
放射治疗
化疗
佐剂
体内
肿瘤科
外科
癌症研究
顺铂
生物
生物技术
作者
Minhua Chen,Chun-Hung Lee,Hsiang-Kuang Tony Liang,Su‐Chin Huang,J M Li,Cheng‐An J. Lin,Jen‐Kun Chen
出处
期刊:Biomaterials advances
日期:2022-09-06
卷期号:141: 213113-213113
被引量:6
标识
DOI:10.1016/j.bioadv.2022.213113
摘要
In most skin cancer patients, excisional surgery is required to remove tumorous tissue. However, the risk of locoregional recurrence after surgery alone is relatively high, particularly for a locally advanced stage of melanoma. Therefore, additional adjuvant treatments, such as radiotherapy, can be used after surgery to inhibit recurrent melanoma after surgical removal. To enhance local radiotherapy, we present the combined X-ray radiation and radiosensitizers (carboplatin) through microneedles (MNs) to treat melanoma. The MNs could be beneficial to precisely delivering carboplatin into the sub-epidermal layer of the melanoma region and alleviate patients' fear and discomfort during the drug administration compared to the traditional local injection. The carboplatin was loaded into the tips of dissolving gelatin MNs (carboplatin-MNs) through the molding method. The results show gelatin MNs have sufficient mechanical strength and can successfully administer carboplatin into the skin. Both in vitro and in vivo studies suggest that carboplatin can enhance radiotherapy in melanoma treatment. With a combination of radiotherapy and carboplatin, the inhibition effect of carboplatin delivered into the B16F10 murine melanoma model through MNs administration (1.2 mg/kg) is equivalent to that through an intravenous route (5 mg/kg). The results demonstrate a promise of combined carboplatin and X-ray radiation treatment in treating melanoma by MNs administration.
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