Body composition, trabecular bone score and vertebral fractures in subjects with Klinefelter syndrome

医学 骨矿物 体质指数 骨小梁评分 瘦体质量 内科学 股骨颈 腰围 单变量分析 骨密度 泌尿科 外科 骨质疏松症 定量计算机断层扫描 多元分析 体重
作者
Walter Vena,Flaminia Carrone,Andrea Delbarba,O. Akpojiyovbi,Letizia Chiara Pezzaioli,Paolo Facondo,Carlo Cappelli,Lorenzo Leonardi,Luca Balzarini,Davide Farina,Alessandro Pizzocaro,Andrea Lania,Gherardo Mazziotti,Alberto Ferlin
出处
期刊:Journal of Endocrinological Investigation [Springer Science+Business Media]
卷期号:46 (2): 297-304 被引量:10
标识
DOI:10.1007/s40618-022-01901-8
摘要

BackgroundKlinefelter syndrome (KS) frequently causes skeletal fragility characterized by profound alterations in bone microstructure with increased risk of fractures. Increased body fat mass associated with decreased body lean mass are frequent features of KS with possible detrimental effects on skeletal health. In this cross-sectional study, we evaluated the associations between body composition parameters, vertebral fractures (VFs) and trabecular bone score (TBS) in adult subjects with KS.MethodsSeventy-one adult males (median age 41 years, range 18–64) with 47, XXY KS were consecutively enrolled by two Endocrinology and Andrology Units (IRCCS Humanitas Research Hospital in Milan and ASST Spedali Civili in Brescia). Dual-energy X-ray absorptiometry (DXA) was performed to assess bone mineral density (BMD) at lumbar spine, femoral neck and total hip, TBS and body composition. Prevalence of VFs was assessed by quantitative morphometry on lateral spine X-rays.ResultsVFs were detected in 14 patients (19.7%), without significant association with low BMD (p = 0.912). In univariate logistic regression analysis, VFs were significantly associated with truncal/leg fat ratio (OR 2.32 per tertile; 95% CI 1.05–5.15; p = 0.038), whereas impaired TBS (detected in 23.4% of subjects) was associated with older age at study entry (p = 0.001) and at diagnosis of disease (p = 0.015), body mass index (BMI; p = 0.001), waist circumference (p = 0.007), fat mass index (FMI; p < 0.001), FMI/lean mass index (LMI) ratio (p = 0.001). Prevalence of VFs was not significantly different between subjects with impaired TBS as compared to those with normal TBS (26.7 vs. 18.4%; p = 0.485). Skeletal end-points were not significantly associated with duration of testosterone replacement therapy and serum testosterone and 25hydroxyvitamin D values.ConclusionBody composition might influence bone quality and risk of VFs in subjects with KS.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小马的可爱老婆完成签到,获得积分10
1秒前
海白完成签到,获得积分10
1秒前
认真的飞扬完成签到,获得积分10
1秒前
墨染樱飞完成签到 ,获得积分10
4秒前
ont-tnt发布了新的文献求助10
4秒前
谦让小蚂蚁完成签到,获得积分10
4秒前
4秒前
4秒前
Michelle完成签到,获得积分10
5秒前
海白发布了新的文献求助10
5秒前
5秒前
tesla完成签到,获得积分10
7秒前
SciGPT应助体贴凌柏采纳,获得10
7秒前
慎二完成签到 ,获得积分10
7秒前
9秒前
慕容冷之完成签到,获得积分10
9秒前
9秒前
leo发布了新的文献求助10
10秒前
ont-tnt完成签到,获得积分10
10秒前
sxd完成签到,获得积分10
11秒前
Daisy完成签到 ,获得积分10
11秒前
嘉1612完成签到,获得积分10
12秒前
12秒前
科研通AI2S应助angrymax采纳,获得10
12秒前
落尘发布了新的文献求助10
13秒前
学不懂数学应助小王采纳,获得10
13秒前
量子星尘发布了新的文献求助10
13秒前
ROOKIE完成签到,获得积分10
14秒前
14秒前
阿胡发布了新的文献求助10
15秒前
15秒前
SYLH应助wodetaiyangLLL采纳,获得10
16秒前
loey完成签到,获得积分10
16秒前
等待的音响完成签到,获得积分10
16秒前
16秒前
孙非完成签到,获得积分10
16秒前
江小鱼在查文献完成签到,获得积分10
17秒前
静xixi完成签到,获得积分20
18秒前
就是躺完成签到 ,获得积分10
19秒前
19秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038388
求助须知:如何正确求助?哪些是违规求助? 3576106
关于积分的说明 11374447
捐赠科研通 3305798
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029