Body composition, trabecular bone score and vertebral fractures in subjects with Klinefelter syndrome

医学 骨矿物 体质指数 骨小梁评分 瘦体质量 内科学 股骨颈 腰围 单变量分析 骨密度 泌尿科 外科 骨质疏松症 定量计算机断层扫描 多元分析 体重
作者
Walter Vena,Flaminia Carrone,Andrea Delbarba,O. Akpojiyovbi,Letizia Chiara Pezzaioli,Paolo Facondo,Carlo Cappelli,Lorenzo Leonardi,Luca Balzarini,Davide Farina,Alessandro Pizzocaro,Andrea Lania,Gherardo Mazziotti,Alberto Ferlin
出处
期刊:Journal of Endocrinological Investigation [Springer Science+Business Media]
卷期号:46 (2): 297-304 被引量:10
标识
DOI:10.1007/s40618-022-01901-8
摘要

BackgroundKlinefelter syndrome (KS) frequently causes skeletal fragility characterized by profound alterations in bone microstructure with increased risk of fractures. Increased body fat mass associated with decreased body lean mass are frequent features of KS with possible detrimental effects on skeletal health. In this cross-sectional study, we evaluated the associations between body composition parameters, vertebral fractures (VFs) and trabecular bone score (TBS) in adult subjects with KS.MethodsSeventy-one adult males (median age 41 years, range 18–64) with 47, XXY KS were consecutively enrolled by two Endocrinology and Andrology Units (IRCCS Humanitas Research Hospital in Milan and ASST Spedali Civili in Brescia). Dual-energy X-ray absorptiometry (DXA) was performed to assess bone mineral density (BMD) at lumbar spine, femoral neck and total hip, TBS and body composition. Prevalence of VFs was assessed by quantitative morphometry on lateral spine X-rays.ResultsVFs were detected in 14 patients (19.7%), without significant association with low BMD (p = 0.912). In univariate logistic regression analysis, VFs were significantly associated with truncal/leg fat ratio (OR 2.32 per tertile; 95% CI 1.05–5.15; p = 0.038), whereas impaired TBS (detected in 23.4% of subjects) was associated with older age at study entry (p = 0.001) and at diagnosis of disease (p = 0.015), body mass index (BMI; p = 0.001), waist circumference (p = 0.007), fat mass index (FMI; p < 0.001), FMI/lean mass index (LMI) ratio (p = 0.001). Prevalence of VFs was not significantly different between subjects with impaired TBS as compared to those with normal TBS (26.7 vs. 18.4%; p = 0.485). Skeletal end-points were not significantly associated with duration of testosterone replacement therapy and serum testosterone and 25hydroxyvitamin D values.ConclusionBody composition might influence bone quality and risk of VFs in subjects with KS.
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