线粒体
细胞器
胞浆
细胞生物学
生物能学
生物
细胞
线粒体融合
细胞内
功能(生物学)
旁分泌信号
细胞室
细胞信号
信号转导
生物化学
线粒体DNA
基因
受体
酶
作者
Ram Prosad Chakrabarty,Navdeep S. Chandel
出处
期刊:The biochemist
[Portland Press]
日期:2022-08-23
卷期号:44 (4): 2-8
被引量:43
摘要
Mitochondria, special double-membraned intracellular compartments or ‘organelles’, are popularly known as the ‘powerhouses of the cell’, as they generate the bulk of ATP used to fuel cellular biochemical reactions. Mitochondria are also well known for generating metabolites for the synthesis of macromolecules (e.g., carbohydrates, proteins, lipids and nucleic acids). In the mid-1990s, new evidence suggesting that mitochondria, beyond their canonical roles in bioenergetics and biosynthesis, can act as signalling organelles began to emerge, bringing a dramatic shift in our view of mitochondria’s roles in controlling cell function. Over the next two and half decades, works from multiple groups have demonstrated how mitochondrial signalling can dictate diverse physiological and pathophysiological outcomes. In this article, we will briefly discuss different mechanisms by which mitochondria can communicate with cytosol and other organelles to regulate cell fate and function and exert paracrine effects. Our molecular understanding of mitochondrial communication with the rest of the cell, i.e. mitochondrial signalling, could reveal new therapeutic strategies to improve health and ameliorate diseases.
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