Wnt信号通路
棕榈酰化
癌症
信号转导
生物
癌症研究
细胞生物学
酶
生物化学
遗传学
半胱氨酸
作者
Mortaza Raeisi,Maryam Saberivand,Kobra Velaei,Negar Aghaei,Nasim Rahimi‐Farsi,Hengameh Kharrati‐Shishavan,Davoud Hassanzadeh,Amir Mehdizadeh
摘要
Wingless-related integration site (Wnt) signaling is one of the main oncogenic pathways in different malignancies. Therefore, targeting this pathway has been considered an exciting strategy in cancer treatment. Porcn is among the central enzymes in this pathway that has recently been considered for cancer-targeted therapy. As a membrane-bound O-acyltransferase, Porcn plays a critical role in wnt ligand palmitoylation and its subsequent secretion. In addition to Porcn's role in stem cell signaling and differentiation, recent findings have shown its role in developing and progressing colorectal, pancreatic, liver, head, and neck cancers. Developed small molecule inhibitors have also opened a promising window toward cancer treatment strategies. In this review, the structure and biological role of Porcn in different cancer-related signaling pathways and inhibitors used for inhibiting this enzyme are discussed.
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