The aims of the study are to investigate the survival status and its influencing factors of pneumoconiosis patients and to analyze the disease burden and its trend in Jiangsu Province.We used the life table and Cox model to analyze the survival status. The disease burden and its temporal trend were examined using the disability-adjusted life years (DALY).The average survival time was 16.22 ± 10.11 years. First diagnosis age, first diagnosis stage, and upgrade of stages were crucial risk factors for the survival. The cumulative DALY was 154,500.83 person-years. The DALY attributed to silicosis, coal worker pneumoconiosis, and welder's pneumoconiosis were 99,806.72 (64.60%), 35,483.21 (22.97%), and 37,85.83 (2.45%) person-years, respectively.Although the disease burden of pneumoconiosis is decreasing because of the implementation of relevant health policies and improved medical standards, the prevention and control of pneumoconiosis still need greater attention.